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  1. Risk factors for Barrett's esophagus in community-based practice.

    Article - En anglais

    Objectives 

    Endoscopy is often performed in patients with gastroesophageal reflux (GER) disease because of concern about the presence of Barrett's esophagus (BE).

    The purpose of this study was to determine whether the duration of GER symptoms and/or a history of esophagitis was associated with an increased risk of BE.

    Methods 

    This was an observational, prospective, community-based study.

    Consecutive patients undergoing elective endoscopy because of GER symptoms were enrolled.

    Endoscopy reports and pathological findings were reviewed to classify patients as having no esophagitis, esophagitis, or probable BE.

    Correlations with duration of symptoms and a history of esophagitis were analyzed.

    Results 

    In all, 701 of 2641 patients (27%) undergoing elective endoscopy had GER symptoms, and 77 of these patients had probable BE.

    Compared with patients with GER symptoms for less than 1 yr, the odds ratio for BE in patients with GER symptoms for 1-5 years was 3.0 and increased to 6.4 in patients with symptoms for more than 10 yr (p<0.001).

    A history of esophagitis was not an independent risk factor for BE (p=0.17).

    Conclusions 

    Prevalence of BE is strongly associated with duration of GER symptoms.

    Mots-clés Pascal : Reflux gastrooesophagien, Oesophagite, Incidence, Complication, Oesophage Barrett, Relation, Temps établissement, Etude statistique, Homme, Appareil digestif pathologie, Oesophage pathologie

    Mots-clés Pascal anglais : Gastroesophageal reflux, Esophagitis, Incidence, Complication, Barrett esophagus, Relation, Onset time, Statistical study, Human, Digestive diseases, Esophageal disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0450427

    Code Inist : 002B13A03. Création : 03/02/1998.