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  1. Competing risks of mortality in prostate cancer.

    Article - En anglais


    We have observed that in prostate cancer older age, black race, high stage and no treatment are independently associated with higher disease specific and overall mortality.

    Because disease nonspecific mortality was not examined one cannot reasonably infer that higher overall mortality is largely due to higher disease specific mortality.

    To understand better the interactions of independent prognostic variables with overall mortality we jointly evaluated their effects on type of death and time to death.

    Materials and Methods 

    Using the prostate cancer patients of the 1973 to 1990 public use tape of the Surveillance, Epidemiology and End Results program, we performed competing risks analysis with multivariate accelerated failure time model to examine if the prognostic factors were associated with type of death and time to death.


    Older age, black race and no treatment were independently associated with higher relative risk of disease specific and nonspecific mortality.

    Localized stage was associated with lower and higher disease specific and nonspecific mortality than regional stage, respectively.

    The relative risks of disease specific and nonspecific mortality were significantly different from each other for all prognostic factors.


    To our knowledge, a competing risks analysis in prostate cancer has not been done previously. (...)

    Mots-clés Pascal : Adénocarcinome, Prostate, Facteur risque, Mortalité, Spécificité, Age, Race, Traitement, Grade histologique, Etude statistique, Homme, Tumeur maligne, Appareil urinaire pathologie, Appareil génital mâle pathologie, Prostate pathologie

    Mots-clés Pascal anglais : Adenocarcinoma, Prostate, Risk factor, Mortality, Specificity, Age, Race, Treatment, Histological grading, Statistical study, Human, Malignant tumor, Urinary system disease, Male genital diseases, Prostate disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0450015

    Code Inist : 002B14D02. Création : 03/02/1998.