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  1. Update on the appropriate staging evaluation for newly diagnosed prostate cancer.

    Article - En anglais


    Prostate cancer clinical staging methods and decision support tools were reviewed to assess their accuracy to predict pathological staging results and determine what comprises an appropriate clinical staging evaluation.

    Materials and Methods 

    The MEDLINE data base was searched and 238 abstracts were obtained.

    Data were extracted from 142 articles that evaluated the preoperative accuracy of digital rectal examination, prostate specific antigen, prostatic acid phosphatase, systematic biopsy parameters (including Gleason scoring), seminal vesicle biopsy, various imaging studies and pelvic lymphadenectomy versus pathological staging results.

    The sensitivity, specificity and accuracy rates were calculated and tabulated from the reported data on each method or decision support tools for organ confined, nonorgan confined and lymph node metastatic tumor.


    Decision support tools based on logistic regression analysis, which combine several statistically independent staging parameters, had greater accuracy than any single clinical staging method alone.

    The most accurate decision support tools for clinical staging combined digital rectal examination (T stage), systematic biopsy parameters (including Gleason scoring) and prostate specific antigen.


    The components that comprise the most accurate decision support tools for clinical staging represent an appropriate staging evaluation for the newly diagnosed prostate cancer patient in 1997. (...)

    Mots-clés Pascal : Adénocarcinome, Prostate, Diagnostic, Classification par stade, Exploration clinique, Antigène spécifique prostate, Acid phosphatase, Phosphoric monoester hydrolases, Esterases, Hydrolases, Enzyme, Exploration cytologique, Tomodensitométrie, Valeur prédictive, Evolution, Revue bibliographique, Homme, Tumeur maligne, Appareil urinaire pathologie, Appareil génital mâle pathologie, Prostate pathologie, Anatomopathologie

    Mots-clés Pascal anglais : Adenocarcinoma, Prostate, Diagnosis, Stage classification, Clinical investigation, Prostate specific antigen, Acid phosphatase, Phosphoric monoester hydrolases, Esterases, Hydrolases, Enzyme, Cytologic investigation, Computerized axial tomography, Predictive value, Evolution, Bibliographic review, Human, Malignant tumor, Urinary system disease, Male genital diseases, Prostate disease, Pathology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0449317

    Code Inist : 002B14D02. Création : 03/02/1998.