Quantitative bronchial challenge tests with flour dust for the diagnosis of bakers'asthma may be performed by inhalation of flour delivered to the patient's respiratory tract by sophisticated equipment.
This study was carried out to assess the diagnostic value of bronchial challenge tests with flour dust inhalation from capsules administered by a Spinhaler (Fisons Inc., Loughborough, U.K.) and to compare this method quantitatively with bronchial challenge tests with a commercially available wheat flour extract.
A highly selected group of 36 bakers with work-related symptoms of rhinitis or asthma were referred to our department, a tertiary referral center, from 1992 to 1995.
Thirty-four of the subjects and 10 atopic control subjects were included in this study.
After the assessment of bronchial hyperresponsiveness on day I, subjects were randomized to inhale an aqueous wheat flour extract at concentrations of 0.01,0.1,1,10, and 100 mg/ml by tidal volume breathing for 10 minutes or to inhale wheat flour dust filled in capsules on days 2 and 3. One, two, and four capsules (maximum of 7 cumulative capsules) of flour dust were administered by a Spinhaler.
In addition, skin prick tests were performed with a battery of environmental and occupational allergens.
Total serum IgE and specific IgE to wheat flour were measured by standard procedures. (...)
Mots-clés Pascal : Asthme, Boulanger, Test provocation, Exposition professionnelle, Bronche, Extrait, Farine blé, Allergène, Poussière, Etude comparative, Inhalation, Solution aqueuse, Diagnostic, Homme, Allemagne, Europe, Appareil respiratoire pathologie, Bronchopneumopathie obstructive, Maladie professionnelle, Médecine travail, Spinhaler
Mots-clés Pascal anglais : Asthma, Baker, Provocation test, Occupational exposure, Bronchus, Extract, Wheat flour, Allergen, Dust, Comparative study, Inhalation, Aqueous solution, Diagnosis, Human, Germany, Europe, Respiratory disease, Obstructive pulmonary disease, Occupational disease, Occupational medicine
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0448292
Code Inist : 002B06E01. Création : 03/02/1998.