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  1. Fulltext. The association of drinking water source and chlorination by-products with cancer incidence among postmenopausal women in Iowa : A prospective cohort study.

    Article - En anglais

    Fulltext.

    Objectives

    This study assessed the association of drinking water source and chlorination by-product exposure with cancer incidence.

    Methods

    A cohort of 28 237 Iowa women reported their drinking water source.

    Exposure to chlorination by-products was determined from statewide water quality data.

    Results

    In comparison with women who used municipal groundwater sources, women with municipal surface water sources were at an increased risk of colon cancer and all cancers combined.

    A clear dose-response relation was observed between four categories of increasing chloroform levels in finished drinking water and the risk of colon cancer and all cancers combined.

    The relative risks were 1.00,1.06,1.39, and 1.68 for colon cancer and 1.00,1.04,1.24. and 1.25 for total cancers.

    No consistent association with either water source or chloroform concentration was observed for other cancer sites.

    Conclusions

    These results suggest that exposure to chlorination by-products in drinking water is associated with increased risk of colon cancer.

    Mots-clés Pascal : Consommation, Eau alimentation, Chloration, Désinfection, Tumeur maligne, Eau surface, Eau souterraine, Toxicité, Epidémiologie, Facteur risque, Incidence, Femme, Homme, Postménopause, Iowa, Etats Unis, Amérique du Nord, Amérique, Santé et environnement, Etude cohorte, Etude comparative

    Mots-clés Pascal anglais : Consumption, Feed water, Chlorination, Disinfection, Malignant tumor, Surface water, Ground water, Toxicity, Epidemiology, Risk factor, Incidence, Woman, Human, Postmenopause, Iowa, United States, North America, America, Health and environment, Cohort study, Comparative study

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0447561

    Code Inist : 002B30A02A. Création : 03/02/1998.