The relation between the dietary intake of vitamins E, C, and A (estimated by a 24-hour recall) and lung cancer incidence was examined in the First National Health and Nutrition Examination Survey Epidemiologic Followup Study cohort of 3,968 men and 6,100 women, aged 25-74 years.
During a median follow-up period of 19 years (from 1971-1975 to 1992), 248 persons developed lung cancer.
Adjusted for potential confounders using Cox proportional hazards regression methods with age as the underlying time variable, the relative risk of lung cancer for subjects in the highest quartile of vitamin C intake compared with those in the lowest quartile was 0.66 (95% confidence interval (Cl) 0.45-0.96).
For vitamin A intake, a protective effect was observed only for its fruit and vegetable component (carotenoids) among current smokers (relative risk=0.49,95% Cl 0.29-0.84), but this was modified by the intensity of smoking (a statistically significant effect (relative risk=0.33,95% Cl 0.13-0.84) was observed only for those in the lowest tertile of pack-years of smoking).
The vitamin E intake-lung cancer relation was modified by the intensity of smoking with a significant protective effect confined to current smokers in the lowest tertile of pack-years of smoking (relative risk=0.36,95% Cl 0.16-0.83).
Overall, there was no additional protective effect of supplements of vitamins E, C, and A beyond that provided through dietary intake. (...)
Mots-clés Pascal : Tumeur maligne, Bronchopulmonaire, Régime alimentaire, Consommation alimentaire, alpha-Tocophérol, Acide ascorbique, Rétinol, Fruit, Légume, Supplémentation, Epidémiologie, Risque, Homme, Etats Unis, Amérique du Nord, Amérique, Prospective, Appareil respiratoire pathologie, Poumon pathologie, Bronche pathologie, Alimentation, Vitamine
Mots-clés Pascal anglais : Malignant tumor, Bronchopulmonary, Diet, Food intake, alpha-Tocopherol, Ascorbic acid, Retinol, Fruit, Vegetable, Supplementation, Epidemiology, Risk, Human, United States, North America, America, Prospective, Respiratory disease, Lung disease, Bronchus disease, Feeding, Vitamin
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0447448
Code Inist : 002B30A02A. Création : 03/02/1998.