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  1. Cold-adapted live attenuated influenza vaccines developed in Russia : Can they contribute to meeting the needs for influenza control in other countries ?

    Article - En anglais

    It is now more than 30 years since the first cold-adapted influenza viruses were developed in Russia as potential live, attenuated vaccines.

    In the past 15-20 years considerable experience has been gained from Russian and joint Russian-US laboratory and clinical studies with type A monovalent and bivalent vaccines prepared with genetic reassortant viruses derived from one of these cold-adapted viruses in particular, A/Leningrad/134/57.

    More recent experiences include use of trivalent cold-adapted vaccines with a type B component.

    The overall high level of safety of individual and combined vaccines in pre-school and school-aged children, with illness reductions in open field trials equivalent to that seen with inactivated vaccines, is such as to suggest that practical measures might now be justified to facilitate expansion of the use of these vaccines to other countries.

    It is proposed that further experimentation with the Russian cold-adapted live attenuated vaccines should be focused on issues that will relate to the public health perspective, i.e. selection of the single best candidiate type A and B vaccines for intense study using as criteria their potential for meeting licensing requirements outside Russia, and documenting the clinical protective efficacy of a single vaccine dose compared to two doses as studied until now. (...)

    Mots-clés Pascal : Grippe, Virose, Infection, Vaccination, Vaccin, Souche atténuée, Efficacité, Immunisation, Relation dose réponse, Essai clinique, Technique, Evaluation performance, Homme, Epidémiologie, Prévention, Russie, Eurasie

    Mots-clés Pascal anglais : Influenza, Viral disease, Infection, Vaccination, Vaccine, Attenuated strain, Efficiency, Immunization, Dose activity relation, Clinical trial, Technique, Performance evaluation, Human, Epidemiology, Prevention, Russia, Eurasia

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0447294

    Code Inist : 002B05A02. Création : 03/02/1998.