The prevalence of antibodies for one or more HCV antigens was 2.3% of 1,347 mothers at childbirth.
Compared with the principal factors studied, the presence of antibodies was more frequent in women who were carriers of HIV infection (3/3), in those who had suffered liver diseases (5/37) or who had had transfusion (3/25).
This was as opposed to women who did not have any risk factor (p<0.001).
The prevalence of HCV-RNA was 1.3% ; in relation to the antibody state, such a condition was more frequent in subjects with antibodies for 3 or 4 antigens (about 80%) compared with those who were positive for 1 or 2 antigens.
HCV-RNA of the same genotype as the mother (type 1 ; 1a) was also found in the funicular blood of 2 of the 18 babies born to mothers who were positive for HCV-RNA.
In the course of the follow-up (from the 3rd to the 18th month) the viral RNA was not found in any of the babies, nor was it found in the 2 who were positive at birth.
Even the antibodies gradually disappeared, although slowly.
At the 10th month, 91% of the babies resulted as having no antibodies and at the 18th month none of the babies resulted as having antibodies.
Breast-feeding also appeared to have no influence on the transmission of the infection ; out of 18 viremic mothers indeed 12 (67%) breast-fed their babies.
Mots-clés Pascal : Hépatite virale C, Virose, Infection, Gestation, Transmission mère enfant, Génotype, Sérologie, Epidémiologie, Prévalence, Facteur risque, Femme, Homme, Italie, Europe, Appareil digestif pathologie, Foie pathologie
Mots-clés Pascal anglais : Viral hepatitis C, Viral disease, Infection, Pregnancy, Mother to child transmission, Genotype, Serology, Epidemiology, Prevalence, Risk factor, Woman, Human, Italy, Europe, Digestive diseases, Hepatic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0447286
Code Inist : 002B05C02G. Création : 03/02/1998.