Background Severe tardive dyskinesia (TD) represents a serious and potentially disabling movement disorder, yet relatively little is known aboutthe incidence of and risk factors for severeTD.
Method We report the results of a longitudinal prospective incidence study of severeTD in 378 middle-aged and elderly neuropsychiatric patients.
Psychiatric, neuropsychological, pharmacological and motor variables were obtained at intake and at regular intervals for 36 months.
Results The cumulative incidence of severeTD was 2.5% after one year, 12.1% after two years, and 22.9% after three years.
Individual univariable Cox regression analyses were conducted to identify demographic, psychiatric, motor and pharmacological predictors of severeTD.
Results indicated that higher daily doses of neuroleptics at study entry, greater cumulative amounts of prescribed neuroleptic, and greater severity of worsening negative symptoms were predictive ofsevereTD.
Conclusions These findings suggest that conventional neuroleptics may be prescribed to older patients only when necessary and at the lowest effective dosage.
Additional caution is recommended in patients exhibiting negative symptoms.
Mots-clés Pascal : Dyskinésie, Tardif, Facteur risque, Incidence, Epidémiologie, Etats Unis, Amérique du Nord, Amérique, Neuroleptique, Psychotrope, Toxicité, Vieillard, Homme, Adulte, Système nerveux pathologie, Trouble neurologique, Mouvement involontaire, Extrapyramidal syndrome
Mots-clés Pascal anglais : Dyskinesia, Late, Risk factor, Incidence, Epidemiology, United States, North America, America, Neuroleptic, Psychotropic, Toxicity, Elderly, Human, Adult, Nervous system diseases, Neurological disorder, Involuntary movement, Extrapyramidal syndrome
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0445781
Code Inist : 002B02U01. Création : 03/02/1998.