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  1. Vitamin E and human health : Rationale for determining recommended intake levels.

    Article - En anglais

    The recent literature provides strong evidence that vitamin E intakes much higher than the current recommendations can contribute to and/or improve human health.

    In fact, the available data indicate that at higher-than-current recommended intake levels, vitamin E affects several functions related to human health.

    For example, Vitamin E is required to protect polyunsaturated fatty acids (PUFAs) against auto-oxidation.

    The amount of vitamin E needed to protect PUFAs against oxidative damage is at least 0.4-0.8 mg vitamin E per gram PUFAs and may be in excess of 1.5 mg/g when diets contain higher-than-average levels of long-chain PUFAs.

    Based upon studies of vitamin E kinetics and metabolism, a daily vitamin E intake of 135-150 IU is suggested.

    Important functions such as protection against oxidative damage, immune response, and the propensity of platelets to adhere to the vessel wall are related to vitamin E intakes.

    Vitamin E intake of 40 lU/d was the least amount demonstrated to inhibit low-density lipoprotein oxidation ; a dose-dependent effect was seen up to 800 IU/d. Vitamin E intakes of at least 60 IU/d enhanced immune responses and intakes of 200 IU-400 IU/d decreased platelet adhesion to the vessel wall.

    Based upon the effects of modulating these functions, it is hypothesized that vitamin E plays a pivotal role in the prevention of cardiovascular diseases.

    Indeed, many observational studies have reported vitamin E to reduce the risk of cardiovascular disease. (...)

    Mots-clés Pascal : alpha-Tocophérol, Besoin nutritif, Recommandation, Antioxydant, Appareil circulatoire pathologie, Tumeur maligne, Réponse immune, Article synthèse, Homme

    Mots-clés Pascal anglais : alpha-Tocopherol, Nutrient requirement, Recommendation, Antioxidant, Cardiovascular disease, Malignant tumor, Immune response, Review, Human

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0445171

    Code Inist : 002B29B. Création : 03/02/1998.