Occult thyroid carcinoma, defined here as an impalpable thyroid carcinoma that is generally smaller than 1.0 cm, is a frequent finding in the general population.
Its prevalence varies according to the geographical location, type and intensity of the pathological examination and history of exposure to ionizing radiation.
It is found at all age groups, but is more frequent after the age of 40 years.
There is no gender difference in the frequency of occult thyroid carcinoma found at autopsy or in surgical specimens removed for other diseases.
Most commonly, it is of the papillary type, and can be classified as sclerosing non-encapsulated (SNE), non-sclerosing encapsulated (NSE) and non-sclerosing non-encapsulated (NSNE) carcinoma.
NSNE may be an early stage in tumor progression, although most of the sclerosing tumors remain clinically silent throughout life.
Occult thyroid carcinoma that is not metastatic has a much better prognosis than clinically apparent thyroid carcinoma ; few tumors recur and almost no one dies of cancer.
However, thyroid capsular invasion and lymph node metastases may occur with occult thyroid carcinomas, and distant metastases which may be fatal have been reported.
Nodal metastases may be the presenting manifestation.
Ultrasonography and scintigraphy can detect impalpable lesions, while fine-needle aspiration biopsy is the best way to assess their malignant nature. (...)
Mots-clés Pascal : Carcinome, Thyroïde, Pathogénie, Epidémiologie, Type histologique, Pronostic, Diagnostic, Traitement, Article synthèse, Homme, Tumeur maligne, Endocrinopathie, Thyroïde pathologie, Carcinome occulte
Mots-clés Pascal anglais : Carcinoma, Thyroid gland, Pathogenesis, Epidemiology, Histological type, Prognosis, Diagnosis, Treatment, Review, Human, Malignant tumor, Endocrinopathy, Thyroid diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0444305
Code Inist : 002B21C02. Création : 03/02/1998.