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  1. Autoantibodies to a nucleolar RNA helicase protein in patients with connective tissue diseases.

    Article - En anglais

    Objective

    An autoantibody to a nucleolar RNA helicase protein (Gu) was recently discovered in a patient with gastric antral vascular ectasia or watermelon stomach, a disorder that is increasingly being described in systemic sclerosis (SSc).

    The present study was undertaken to determine whether anti-Gu antibodies occur in connective tissue diseases (CTD) and, if so, to determine their frequencies and any clinical or immunogenetic associations.

    Methods

    Anti-Gu antibodies were determined by Western blotting of glutathione-purified glutathione S transferase-Gu fusion proteins against consecutive antinucleolar antibody-positive sera (HEp-2 cell substrate) collected over a 5-year period in a rheumatology antinuclear antibody (ANA) testing laboratory.

    Results

    Anti-Gu antibodies were found in 11 (10%) of 108 antinucleolar antibody-positive sera.

    The subjects with anti-Gu antibodies included 3 of 46 patients with SSc (7%), 3 of 17 patients with systemic lupus erythematosus (18%), 4 of 9 patients with undifferentiated CTD (44%), and 1 healthy relative of an SSc patient.

    None of the anti-Gu-positive patients had any symptoms suggestive of watermelon stomach.

    Increased frequencies of both HLA-DQA1*0501 and DQB1*0301 were found, but only DQB1*0301 maintained statistical significance after correction. (...)

    Mots-clés Pascal : Tissu conjonctif pathologie, Pathogénie, Anticorps, Autoanticorps, RNA nucléaire, Sérum, Epidémiologie, Fréquence, Symptomatologie, Antigène histocompatibilité classe II, Allèle, Exploration, Homme, Peau pathologie, Maladie autoimmune, Immunopathologie, Maladie système, Antigène Gu

    Mots-clés Pascal anglais : Connective tissue disease, Pathogenesis, Antibody, Autoantibody, Nuclear RNA, Serum, Epidemiology, Frequency, Symptomatology, Class II histocompatibility antigen, Allele, Exploration, Human, Skin disease, Autoimmune disease, Immunopathology, Systemic disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0443873

    Code Inist : 002B07. Création : 03/02/1998.