An autoantibody to a nucleolar RNA helicase protein (Gu) was recently discovered in a patient with gastric antral vascular ectasia or watermelon stomach, a disorder that is increasingly being described in systemic sclerosis (SSc).
The present study was undertaken to determine whether anti-Gu antibodies occur in connective tissue diseases (CTD) and, if so, to determine their frequencies and any clinical or immunogenetic associations.
Anti-Gu antibodies were determined by Western blotting of glutathione-purified glutathione S transferase-Gu fusion proteins against consecutive antinucleolar antibody-positive sera (HEp-2 cell substrate) collected over a 5-year period in a rheumatology antinuclear antibody (ANA) testing laboratory.
Anti-Gu antibodies were found in 11 (10%) of 108 antinucleolar antibody-positive sera.
The subjects with anti-Gu antibodies included 3 of 46 patients with SSc (7%), 3 of 17 patients with systemic lupus erythematosus (18%), 4 of 9 patients with undifferentiated CTD (44%), and 1 healthy relative of an SSc patient.
None of the anti-Gu-positive patients had any symptoms suggestive of watermelon stomach.
Increased frequencies of both HLA-DQA1*0501 and DQB1*0301 were found, but only DQB1*0301 maintained statistical significance after correction. (...)
Mots-clés Pascal : Tissu conjonctif pathologie, Pathogénie, Anticorps, Autoanticorps, RNA nucléaire, Sérum, Epidémiologie, Fréquence, Symptomatologie, Antigène histocompatibilité classe II, Allèle, Exploration, Homme, Peau pathologie, Maladie autoimmune, Immunopathologie, Maladie système, Antigène Gu
Mots-clés Pascal anglais : Connective tissue disease, Pathogenesis, Antibody, Autoantibody, Nuclear RNA, Serum, Epidemiology, Frequency, Symptomatology, Class II histocompatibility antigen, Allele, Exploration, Human, Skin disease, Autoimmune disease, Immunopathology, Systemic disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0443873
Code Inist : 002B07. Création : 03/02/1998.