To determine, in a case-control study, if patients with new-onset juvenile dermatomyositis (juvenile DM) have increased symptoms prior to onset, exposure to certain environmental conditions, frequency of familial autoimmune diseases, or antibody titers, compared with 2 control groups.
A structured interview with the families of 80 children with juvenile DM, 40 children with juvenile rheumatoid arthritis (JRA), or 23 healthy children, from the same geographic area as the children with juvenile DM, was conducted.
All children's sera were tested for antibody to Toxoplasma gondii, herpes simplex virus (HSV), or coxsackievirus B (CVB).
A high proportion of children with juvenile DM had constitutional symptoms 3 months before the disease-onset date (P=0.013 versus control children).
Children with JRA had more relatives with rheumatoid arthritis (P=0.0001) and pernicious anemia (P=0.003) than did children with juvenile DM or healthy children.
Among children ¾7 years of age, elevated enteroviral titers were more frequent in those with juvenile DM (81%) and in healthy controls (90%) than in those with JRA (64%), suggesting a common environmental exposure.
Titers to T gondii, HSV, or CVB 1-6 were normal.
Frequencies of familial autoimmune disease, exposure to environmental factors, or elevated antibody titers to T gondii, HSV, or CVB are not increased in juvenile DM. (...)
Mots-clés Pascal : Dermatomyosite, Enfant, Homme, Pathogénie, Epidémiologie, Facteur risque, Facteur milieu, Infection, Symptomatologie, Milieu familial, Arthrite chronique juvénile, Etude comparative, Chronique, Peau pathologie, Tissu conjonctif pathologie, Muscle strié pathologie, Maladie système, Maladie autoimmune, Immunopathologie, Virose, Système ostéoarticulaire pathologie, Rhumatisme inflammatoire
Mots-clés Pascal anglais : Dermatomyositis, Child, Human, Pathogenesis, Epidemiology, Risk factor, Environmental factor, Infection, Symptomatology, Family environment, Juvenile rheumatoid arthritis, Comparative study, Chronic, Skin disease, Connective tissue disease, Striated muscle disease, Systemic disease, Autoimmune disease, Immunopathology, Viral disease, Diseases of the osteoarticular system, Inflammatory joint disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0443462
Code Inist : 002B07. Création : 03/02/1998.