A case-control study of diet and prostate cancer.
We interviewed 328 men diagnosed with prostate cancer before the age of 75 years and 328 age-matched population controls.
The principal hypotheses were that risk would increase with a high intake of total or saturated fat and would decrease with a high intake of carotene (bêta-carotene equivalents) or lycopene.
We also examined the associations of other nutrients and foods with risk.
There was no evidence for an association between fat intake and risk, although the average fat intake was high and the range of fat intakes was narrow (medians of lower and upper thirds of percentage of energy from fat among controls were 34.3% and 42.9% respectively).
Risk was lower in subjects with higher carotene intake : odds ratios 0.65 (95% Cl 0.45-0.94) and 0.76 (0.53-1.10) in the middle and upper thirds of carotene intake respectively (Pfor trend=0.150).
Lycopene was not associated with risk.
Among 13 other nutrients examined, the odds ratios in the top third of intake were below 0.8 for :
potassium, 0.74 (0.51-1.09 ; P for trend=0.054) ;
zinc, 0.73 (0.49-1.08 ; P for trend=0.126) ;
iodine, 0.75 (0.51-1.1 1 ; P for trend=0.077) ;
vitamin B6 food only, 0.77 (0.53-1.12 ; P for trend=0.077) ;
and vitamin B6 including supplements, 0.70 (0.48-1.03 ; P for trend=0.029).
Among 18 foods examined, statistically significant associations were observed for : garlic as food, 2 2/week vs never, 0.56 (0.33-0.93) ; garlic including supplements, 2 2/week vs never, 0.60 (0.37-0.96) (...)
Mots-clés Pascal : Tumeur maligne, Prostate, Epidémiologie, Facteur risque, Homme, Régime alimentaire, Lipide, Nutriment, Carotène, Lycopène, Aliment, Etude cas témoin, Appareil génital mâle pathologie, Appareil urinaire pathologie, Prostate pathologie
Mots-clés Pascal anglais : Malignant tumor, Prostate, Epidemiology, Risk factor, Human, Diet, Lipids, Nutrient, Carotene, Food, Case control study, Male genital diseases, Urinary system disease, Prostate disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0441964
Code Inist : 002B14D02. Création : 03/02/1998.