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  1. Chagas'disease : A search for treatment and a question-should the disease be of military concern ?

    Article - En anglais

    If military forces are required to operate in areas that are endemic for Chagas'disease, the occupation should be of critical concern.

    These areas, located in Central and South America, are many.

    The matter is of particular importance because no suitable drug exists to treat individuals who contract the disease.

    We examined 60 compounds of a chemical class, thiosemicarbazones, known to have some activity against the disease.

    The work was carried out using Trypanosoma cruzi-infected mice.

    Of the 60 potential drugs evaluated, 12 showed significant suppressive activity.

    One of these compounds was almost 50% greater than the reference drug used in the test system.

    Mots-clés Pascal : Trypanosomiase américaine, Trypanosomiase, Protozoose, Parasitose, Infection, Epidémiologie, Région géographique, Protocole thérapeutique, Prévalence, Relation hôte parasite, Thiosemicarbazone, Evaluation, Prévention, Militaire, Etats Unis, Amérique du Nord, Amérique, Chimiothérapie

    Mots-clés Pascal anglais : Chagas disease, Trypanosomiasis, Protozoal disease, Parasitosis, Infection, Epidemiology, Geographical division, Therapeutic protocol, Prevalence, Host parasite relation, Thiosemicarbazone, Evaluation, Prevention, Military, United States, North America, America, Chemotherapy

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0438597

    Code Inist : 002B05E02B6. Création : 19/12/1997.