Cancer is one of the leading causes of death today, and new therapeutic approaches are continuously being explored.
In recent years, cancer vaccines have been tried with the aim of induction of an active specific immune response against the tumor.
Although some successful results are obtained, cure rates are still disappointing.
The main reason for failure is that vaccines are applied to patients diagnosed with cancer ; in these patients, tumor cell burden is so high that it is almost impossible to overcome the disease by increasing the immune response with vaccines at this stage.
This hypothesis is based on the following idea : since therapy for cancer is unsuccessful in the majority of patients, methods of prevention should be improved.
Immunization against microorganisms has largely prevented morbidity and mortality from infectious disease.
In a similar way, if we immunize people before the development of malignant disease with tumor-specific vaccines, than prevention of cancer may be possible.
Mots-clés Pascal : Tumeur maligne, Epidémiologie, Hypothèse, Antigène spécifique tumeur, Vaccin, Prévention, Homme, Carcinogenèse, Immunoprophylaxie
Mots-clés Pascal anglais : Malignant tumor, Epidemiology, Hypothesis, Tumor specific antigen, Vaccine, Prevention, Human, Carcinogenesis, Immunoprophylaxis
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0438483
Code Inist : 002B04B. Création : 19/12/1997.