Background Hydrochlorofluorocarbons (HCFCS) are used increasingly in industry as substitutes for ozone-depleting chlorofluorocarbons (CFCs).
Limited studies in animals indicate potential hepatotoxicity of some of these compounds.
We investigated an epidemic of liver disease in nine industrial workers who had had repeated accidental exposure to a mixture of 1,1-dichloro-2,2,2-trifluoroethane (HCFC 123) and 1-chloro-1,2,2,2-tetrafluoroethane (HCFC 124).
All nine exposed workers were affected to various degrees.
Both compounds are metabolised in the same way as 1-bromo-1-chloro-2,2,2-trifluoroethane (halothane) to form reactive trifluoroacetyl halide intermediates, which have been implicated in the hepatotoxicity of halothane.
We aimed to test whether HCFCs 123 and 124 can result in serious liver disease.
Methods For one severely affected worker liver biopsy and immunohistochemical stainings for the presence of trifluoroacetyl protein adducts were done.
The serum of six affected workers and five controls was tested for autoantibodies that react with human liver cytochrome-P450 2E1 (P450 2E1) and P58 protein disulphide isomerase isoform (P58).
Findings The liver biopsy sample showed hepatocellular necrosis which was prominent in perivenular zone three and extended focally from portal tracts to portal tracts and centrilobular areas (bridging necrosis).
Trifluoroacetyl-adducted proteins were detected in surviving hepatocytes. (...)
Mots-clés Pascal : Hépatite, Epidémiologie, Facteur risque, Chlorhydrate, Hydrocarbure fluoré, Diagnostic, Biopsie, Etude cas, Ozone, Immunohistochimie, Homme, Appareil digestif pathologie, Foie pathologie, Toxicologie, Activité biologique, Traitement instrumental, Anatomopathologie
Mots-clés Pascal anglais : Hepatitis, Epidemiology, Risk factor, Hydrochlorides, Fluorocarbon, Diagnosis, Biopsy, Case study, Ozone, Immunohistochemistry, Human, Digestive diseases, Hepatic disease, Toxicology, Biological activity, Instrumentation therapy, Pathology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0438457
Code Inist : 002B03L06. Création : 19/12/1997.