Prevention of central venous catheter-related bloodstream infection by use of an antiseptic-impregnated catheter : A randomized, controlled trial.
Bloodstream infection related to short-term use of noncuffed central venous catheters is a common and serious problem.
Technologic innovations to reduce the risk for these infections are needed.
To determine 1) the efficacy of a novel antiseptic catheter in preventing central venous catheter-related infection, 2) patient tolerance of this catheter, and 3) the sources of bloodstream infection originating from noncuffed, multilumen central venous catheters.
Randomized, controlled clinical trial.
Medical-surgical intensive care unit of a 450-bed university hospital.
158 adults scheduled to receive a central venous catheter ; 403 catheters were studied.
Participants received either a standard triple-lumen polyurethane catheter or a catheter that was indistinguishable from the standard catheter and was impregnated with chlorhexidine and silver sulfadiazine.
Catheters were studied for colonization and catheter-related bloodstream infection at removal ; local and systemic effects of catheters were assessed.
The origin of each catheter-associated bloodstream infection was sought by culturing all potential sources (skin, catheter segments, hubs, and infusate) and confirmed by restriction-fragment DNA subtyping.
Antiseptic catheters were less likely to be colonized at removal than control catheters.
(13.5 compared with 24.1 colonized catheters per 100 catheters ; relative risk, (...)
Mots-clés Pascal : Forme sanguine, Infection, Randomisation, Antiseptique, Matériau imprégné, Cathéter, Veine centrale, Prévention, Evaluation, Rapport coût bénéfice, Article synthèse, Homme, Hémogramme, Chimiothérapie, Appareil circulatoire pathologie, Vaisseau sanguin pathologie
Mots-clés Pascal anglais : Blood stream form, Infection, Randomization, Antiseptic, Impregnated material, Catheter, Central vein, Prevention, Evaluation, Cost benefit ratio, Review, Human, Blood cell count, Chemotherapy, Cardiovascular disease, Vascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0438230
Code Inist : 002B02S07. Création : 19/12/1997.