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  1. Prevention of central venous catheter-related bloodstream infection by use of an antiseptic-impregnated catheter : A randomized, controlled trial.

    Article - En anglais


    Bloodstream infection related to short-term use of noncuffed central venous catheters is a common and serious problem.

    Technologic innovations to reduce the risk for these infections are needed.


    To determine 1) the efficacy of a novel antiseptic catheter in preventing central venous catheter-related infection, 2) patient tolerance of this catheter, and 3) the sources of bloodstream infection originating from noncuffed, multilumen central venous catheters.


    Randomized, controlled clinical trial.


    Medical-surgical intensive care unit of a 450-bed university hospital.


    158 adults scheduled to receive a central venous catheter ; 403 catheters were studied.


    Participants received either a standard triple-lumen polyurethane catheter or a catheter that was indistinguishable from the standard catheter and was impregnated with chlorhexidine and silver sulfadiazine.


    Catheters were studied for colonization and catheter-related bloodstream infection at removal ; local and systemic effects of catheters were assessed.

    The origin of each catheter-associated bloodstream infection was sought by culturing all potential sources (skin, catheter segments, hubs, and infusate) and confirmed by restriction-fragment DNA subtyping.


    Antiseptic catheters were less likely to be colonized at removal than control catheters.

    (13.5 compared with 24.1 colonized catheters per 100 catheters ; relative risk, (...)

    Mots-clés Pascal : Forme sanguine, Infection, Randomisation, Antiseptique, Matériau imprégné, Cathéter, Veine centrale, Prévention, Evaluation, Rapport coût bénéfice, Article synthèse, Homme, Hémogramme, Chimiothérapie, Appareil circulatoire pathologie, Vaisseau sanguin pathologie

    Mots-clés Pascal anglais : Blood stream form, Infection, Randomization, Antiseptic, Impregnated material, Catheter, Central vein, Prevention, Evaluation, Cost benefit ratio, Review, Human, Blood cell count, Chemotherapy, Cardiovascular disease, Vascular disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0438230

    Code Inist : 002B02S07. Création : 19/12/1997.