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  1. Seizures in acute stroke : Predictors and prognostic significance : The Copenhagen Stroke Study.

    Article - En anglais

    Background Despite the common occurrence of seizures during the early phase of stroke (ES), the effect of ES on prognosis is not known.

    We determined the relationships between ES and stroke outcome and identified predictors of ES.

    Methods In this community-based study, we prospectively and consecutively studied 1197 patients with acute stroke.

    We determined the number and type of seizures, initial stroke severity, infarct size, mortality, and outcome in survivors.

    Stroke severity was measured on admission, weekly, and at discharge using the Scandinavian Stroke Scale (SSS).

    Multiple logistic and linear regression outcome analyses included relevant confounders and potential predictors, including age, gender, stroke severity on admission, atrial fibrillation, ischemic heart disease, diabetes, blood glucose level on admission, claudication, and hypertension.

    Results Fifty patients (4.2%) had seizures within 14 days of the stroke.

    In the multivariate analyses, only initial stroke severity was related to ES ; stroke type and lesion localization were not related.

    For each 10-point increase in stroke severity (SSS score), the relative risk of ES increased by a factor of 1.65 (95% confidence interval, 1.4 to 1.9) (P<. 0001).

    ES did not influence the risk of death during hospital stay (P=56).

    In survivors, ES was related to a better outcome, equivalent to an increased SSS score of 5.7 points (SE [b]=1.8 ; P=002).

    Conclusions The decisive factor of ES was initial stroke severity. (...)

    Mots-clés Pascal : Accident cérébrovasculaire, Aigu, Epilepsie, Crise, Phase initiale, Danemark, Europe, Facteur prédictif, Pronostic, Homme, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Cérébrovasculaire pathologie, Appareil circulatoire pathologie, Vaisseau sanguin pathologie

    Mots-clés Pascal anglais : Stroke, Acute, Epilepsy, Crisis, Early phase, Denmark, Europe, Predictive factor, Prognosis, Human, Nervous system diseases, Central nervous system disease, Cerebral disorder, Cerebrovascular disease, Cardiovascular disease, Vascular disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0437986

    Code Inist : 002B17C. Création : 19/12/1997.