Reduced final height and indications for insulin resistance in 20 year olds born small for gestational age : regional cohort study.
To investigate whether the association between low birth weight and increased risk of developing impaired glucose tolerance, insulin resistance, hyperglyceridaemia, and hypertension in middle age is apparent by the age of 20 in people born small for gestational age.
Regional cohort study.
Maternity registry, Haguenau, France.
236 fall term singleton babies born small for gestational age (birth weight or length, or both, below third centile) during 1971-8 and 281 with normal birth weight (between 25th and 75th centile).
All subjects were contacted and evaluated at a mean (SD) age of 20.6 (2.1) years.
Main outcome measures
Adult height ; concentrations of glucose, insulin, and proinsulin during an oral glucose tolerance test ; lipid and fibrinogen concentrations ; and blood pressure.
After sex and target height were adjusted for, subjects who had been born small for gestational age were significantly shorter at age 20 than those with a normal birth weight (men 4.5 cm shorter (95% confidence interval 6.0 to 3.0 cm) ; women 3.94 cm shorter (5.2 to 2.7 cm)). (...)
Mots-clés Pascal : Diabète insulinorésistant, Intolérance, Glucose, Hypertriglycéridémie, Hypertension artérielle, Poids naissance faible, France, Europe, Facteur risque, Epidémiologie, Adulte jeune, Homme, Etude longitudinale, Lipide, Endocrinopathie, Métabolisme pathologie, Dyslipémie, Hyperlipoprotéinémie, Enzymopathie, Appareil circulatoire pathologie, Gestation pathologie, Prématurité, Nouveau né pathologie
Mots-clés Pascal anglais : Insulinoresistant diabetes, Intolerance, Glucose, Hypertriglyceridemia, Hypertension, Low birth weight, France, Europe, Risk factor, Epidemiology, Young adult, Human, Follow up study, Lipids, Endocrinopathy, Metabolic diseases, Dyslipemia, Hyperlipoproteinemia, Enzymopathy, Cardiovascular disease, Pregnancy disorders, Prematurity, Newborn diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0437360
Code Inist : 002B21E01A. Création : 19/12/1997.