Influence of polymorphisms of GSTM1 and GSTT1 for risk of renal cell cancer in workers with long-term high occupational exposure to trichloroethene.
Suspected nephrocarcinogenic effects of trichloroethene (TRI) in humans are attributed to metabolites derived from the glutathione transferase (GST) pathway.
The influence of polymorphisms of GSTMI and GSTT1 isoenzymes on the risk of renal cell cancer in subjects having been exposed to high levels of TRI over many years was investigated.
GSTMI and GSTTI genotypes were determined by internal standard controlled polymerase chain reaction.
Fourty-five cases with histologically verified renal cell cancer and a history of long-term occupational exposure to high concentrations of TRI were studied.
A reference group consisted of 48 workers from the same geographical region with similar histories of occupational exposures to TRI but not suffering from any cancer.
Among the 45 renal cell cancer patients, 27 carried at least one functional GSTM I gene (GSTM1+) and 18 at least one functional GSTTI gene (GSTTI+). Among the 48 reference workers, 17 were GSTMl+and 31 were GSTTI+Odds ratios for renal cell cancer were 2.7 for GSTM1+individuals (95% CI, 1.18 6.33 ; P<0.02) and 4.2 for GSTT1+individuals (95% Cl, I. 16-14.91 ; P<0.05), respectively.
The data support the present concept of the nephrocarcinogenicity of TRI.
Mots-clés Pascal : Ethylène(trichloro), Solvant organique, Toxicité, Chronique, Exposition professionnelle, Médecine travail, Homme, Facteur risque, Tumeur maligne, Rein, Toxicogénétique, Génétique, Prédisposition, Polymorphisme, Glutathione transferase, Transferases, Enzyme
Mots-clés Pascal anglais : Ethylene(trichloro), Organic solvent, Toxicity, Chronic, Occupational exposure, Occupational medicine, Human, Risk factor, Malignant tumor, Kidney, Toxicogenetics, Genetics, Predisposition, Polymorphism, Glutathione transferase, Transferases, Enzyme
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0437341
Code Inist : 002B03L04. Création : 19/12/1997.