In this study, we summarize 47 epidemiologic studies related to formaldehyde exposure and use meta-analytic techniques to assess findings for cancers of the lung, nose/nasal sinuses, and nasophalynx.
Our analyses indicate that workers with formaldehyde exposure have essentially null findings foT lung cancer and a slight deficit ofsinonasal cancer.
Nasophalyngeal cancer rates were elevated moderately in a minority of studies.
Most studies, however, did not find any nasopharyngeal cancers, and many failed to report their findings.
After correcting for underreporting, we found a meta relative risk of 1.0 for cohort studies.
Case-control studies had a meta relative risk all.3. Our review of the exposure literature indicated that the nasopharyngeal cancer case-control studies represented much lower and less certain exposures than the cohort studies.
We conclude that the available studies do not support a causal relation between formaldehyde exposure and nasophalyngeal cancer.
This conclusion conflicts with conclusions from two previous meta-analyses, primarily because of our consideration of unreported data.
Mots-clés Pascal : Carcinogène, Formaldéhyde, Epidémiologie, Tumeur maligne, Bronchopulmonaire, Nez, Nasopharynx, Voie respiratoire supérieure, Métaanalyse, Etude cas témoin, Exposition professionnelle, Médecine travail, Toxicité, Homme, ORL pathologie, Appareil respiratoire pathologie, Poumon pathologie, Bronche pathologie
Mots-clés Pascal anglais : Carcinogen, Formaldehyde, Epidemiology, Malignant tumor, Bronchopulmonary, Nose, Nasopharynx, Upper respiratory tract, Metaanalysis, Case control study, Occupational exposure, Occupational medicine, Toxicity, Human, ENT disease, Respiratory disease, Lung disease, Bronchus disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0435205
Code Inist : 002B11A. Création : 19/12/1997.