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  1. An updated meta-analysis of formaldehyde exposure and upper respiratory tract cancers.

    Article - En anglais

    In this study, we summarize 47 epidemiologic studies related to formaldehyde exposure and use meta-analytic techniques to assess findings for cancers of the lung, nose/nasal sinuses, and nasophalynx.

    Our analyses indicate that workers with formaldehyde exposure have essentially null findings foT lung cancer and a slight deficit ofsinonasal cancer.

    Nasophalyngeal cancer rates were elevated moderately in a minority of studies.

    Most studies, however, did not find any nasopharyngeal cancers, and many failed to report their findings.

    After correcting for underreporting, we found a meta relative risk of 1.0 for cohort studies.

    Case-control studies had a meta relative risk all.3. Our review of the exposure literature indicated that the nasopharyngeal cancer case-control studies represented much lower and less certain exposures than the cohort studies.

    We conclude that the available studies do not support a causal relation between formaldehyde exposure and nasophalyngeal cancer.

    This conclusion conflicts with conclusions from two previous meta-analyses, primarily because of our consideration of unreported data.

    Mots-clés Pascal : Carcinogène, Formaldéhyde, Epidémiologie, Tumeur maligne, Bronchopulmonaire, Nez, Nasopharynx, Voie respiratoire supérieure, Métaanalyse, Etude cas témoin, Exposition professionnelle, Médecine travail, Toxicité, Homme, ORL pathologie, Appareil respiratoire pathologie, Poumon pathologie, Bronche pathologie

    Mots-clés Pascal anglais : Carcinogen, Formaldehyde, Epidemiology, Malignant tumor, Bronchopulmonary, Nose, Nasopharynx, Upper respiratory tract, Metaanalysis, Case control study, Occupational exposure, Occupational medicine, Toxicity, Human, ENT disease, Respiratory disease, Lung disease, Bronchus disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0435205

    Code Inist : 002B11A. Création : 19/12/1997.