Under the project of evaluating the health status of the employees of CHEMKO factory (East Slovakia) which produced PCBs between 1955 and 1985, the level of bêta2-microglobulin (bêta2-m) was measured in the serum of 242 subjects from CHEMKO (Group A) and two control groups from much less polluted areas : 1. 277 females from a small mountainous village (Group B), 2. 179 adults from the area of a large city of Kosice (Group C).
The level of thymidine kinase (TK) was measured in the groups A and B only.
In addition, age-matched groups of 155 women each from all areas were evaluated.
In both the whole group and the age-matched group from CHEMKO the level of bêta2-m was significantly lower (P<0.001) than that in the respective control groups, while no difference was found in the level of TK.
In conclusion, it is suggested that the decrease of bêta2-m in CHEMKO employees might be related to the immunotoxic effects of organochlorines.
Mots-clés Pascal : Biphényle(polychloro), Slovaquie, Europe, Toxicité, Exposition professionnelle, Médecine travail, Immunopathologie, Microglobuline bêta2, Surveillance biologique, Marqueur biologique, Thymidine kinase, Transferases, Enzyme, Sang, Liquide biologique, Homme, Industrie chimique
Mots-clés Pascal anglais : Polychlorobiphenyl, Slovakia, Europe, Toxicity, Occupational exposure, Occupational medicine, Immunopathology, bêta2-Microglobulin, Biological monitoring, Biological marker, Thymidine kinase, Transferases, Enzyme, Blood, Biological fluid, Human, Chemical industry
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0434548
Code Inist : 002B03L06. Création : 19/12/1997.