Despite the widespread prevalence and serious clinical sequelae of infection with Helicobacter pylori, there have been few large population-based studies, using randomly selected subjects, examining the epidemiology of this infection.
To examine the distribution and determinants of H. pylori infection in a developed country.
Overall 4742 subjects, aged 12-64, from Northern Ireland were randomly selected.
Helicobacter pylori specific IgG antibodies were measured by enzyme linked immunosorbent assay, using an acid-glycine extract antigen, in stored serum from subjects who had participated in three linked population-based surveys of cardiovascular risk factors performed in 1986 and 1987.
The overall prevalence of H. pylori infection was 50.5%. Prevalence increased with age from 23.4% in 12-14 year olds to 72.7% in 60-64 year olds : X2 for trend 518, P<10-4.
In subjects aged =25, infection was more common in males (60.9%) than females (55.2%) : X2=9.53, P<0.01.
This relation remained significant after adjusting for age, and measures of socioeconomic class : odds ratio (OR) for infection, male versus female was 1.19 (95% confidence interval [CI] : 1.02-1.40).
Infection was associated with social class : the adjusted OR of infection in subjects from manual social classes relative to those from non-manual classes was 1.7 (95% Cl : 1.47-1.98). (...)
Mots-clés Pascal : Helicobacter pylori, Spirillaceae, Spirillales, Bactérie, Infection, Statut socioéconomique, Démographie, Age, Sexe, Mode de vie, Tabagisme, Consommation, Boisson alcoolisée, Epidémiologie, Prévalence, Facteur risque, Homme, Irlande, Europe
Mots-clés Pascal anglais : Helicobacter pylori, Spirillaceae, Spirillales, Bacteria, Infection, Socioeconomic status, Demography, Age, Sex, Life habit, Tobacco smoking, Consumption, Alcoholic beverage, Epidemiology, Prevalence, Risk factor, Human, Ireland, Europe
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0432832
Code Inist : 002B05B02F. Création : 19/12/1997.