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  1. Epidemiology of Helicobacter pylori infection among 4742 randomly selected subjects from Northern Ireland.

    Article - En anglais

    Background

    Despite the widespread prevalence and serious clinical sequelae of infection with Helicobacter pylori, there have been few large population-based studies, using randomly selected subjects, examining the epidemiology of this infection.

    Aim

    To examine the distribution and determinants of H. pylori infection in a developed country.

    Subjects and Setting

    Overall 4742 subjects, aged 12-64, from Northern Ireland were randomly selected.

    Methods

    Helicobacter pylori specific IgG antibodies were measured by enzyme linked immunosorbent assay, using an acid-glycine extract antigen, in stored serum from subjects who had participated in three linked population-based surveys of cardiovascular risk factors performed in 1986 and 1987.

    Results

    The overall prevalence of H. pylori infection was 50.5%. Prevalence increased with age from 23.4% in 12-14 year olds to 72.7% in 60-64 year olds : X2 for trend 518, P<10-4.

    In subjects aged =25, infection was more common in males (60.9%) than females (55.2%) : X2=9.53, P<0.01.

    This relation remained significant after adjusting for age, and measures of socioeconomic class : odds ratio (OR) for infection, male versus female was 1.19 (95% confidence interval [CI] : 1.02-1.40).

    Infection was associated with social class : the adjusted OR of infection in subjects from manual social classes relative to those from non-manual classes was 1.7 (95% Cl : 1.47-1.98). (...)

    Mots-clés Pascal : Helicobacter pylori, Spirillaceae, Spirillales, Bactérie, Infection, Statut socioéconomique, Démographie, Age, Sexe, Mode de vie, Tabagisme, Consommation, Boisson alcoolisée, Epidémiologie, Prévalence, Facteur risque, Homme, Irlande, Europe

    Mots-clés Pascal anglais : Helicobacter pylori, Spirillaceae, Spirillales, Bacteria, Infection, Socioeconomic status, Demography, Age, Sex, Life habit, Tobacco smoking, Consumption, Alcoholic beverage, Epidemiology, Prevalence, Risk factor, Human, Ireland, Europe

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0432832

    Code Inist : 002B05B02F. Création : 19/12/1997.