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  1. Incidence and prevalence of primary biliary cirrhosis in the city of Newcastle upon Tyne, England.

    Article - En anglais


    To describe the incidence and prevalence of primary biliary cirrhosis in an urban population between 1987 and 1994, using stringent inclusion criteria and a well-defined study area and population.


    Descriptive study based on a case register compiled by a retrospective and prospective case-finding exercise and examination of case notes.


    The city of Newcastle upon Tyne.

    Main Inclusion Criteria

    (1) Definite cases :

    • fulfilling all three of the following diagnostic criteria : positive antimitochondrial antibody (AMA) = 1 : 40 ;

    • cholestatic liver function tests (LFT) ;

    • diagnostic or compatible liver histology. (2) Probable cases : fulfilling two of these criteria.


    All cases of primary biliary cirrhosis identified by multiple case-finding methods, alive from 1 January 1987 to 31 December 1994, in the defined area.

    Main Outcome Measurements

    Incidence and point prevalence rates by age and sex.


    In all, 202 potential cases were identified, of whom 160 met at least two inclusion criteria.

    In definite cases annual incidence varied from 14 to 32 (mean 22) per million whole population (with no clear trend) and point prevalence rose from 180 per million in 1987 to 240 in 1994.

    Mean age at diagnosis in cases incident during the study period was 63.2 years (S.D. 11.1 years, range 39.8-85.7 years). (...)

    Mots-clés Pascal : Cirrhose biliaire, Primitif, Epidémiologie, Incidence, Prévalence, Homme, Angleterre, Grande Bretagne, Royaume Uni, Europe, Zone urbaine, Appareil digestif pathologie, Foie pathologie, Voie biliaire pathologie, Immunopathologie, Maladie autoimmune

    Mots-clés Pascal anglais : Biliary cirrhosis, Primitive, Epidemiology, Incidence, Prevalence, Human, England, Great Britain, United Kingdom, Europe, Urban area, Digestive diseases, Hepatic disease, Biliary tract disease, Immunopathology, Autoimmune disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0432827

    Code Inist : 002B13C03. Création : 19/12/1997.