Prevalence and antifungal susceptibility of vaginal yeasts in outpatients attending a gynecological center in Ancona, Italy.
Between February 1993 and May 1994 we studied the prevalence of fungal vulvovaginitis among women attending the Obstetric and Gynecology Clinic of the University of Ancona.
Out of the 222 patients, 18 (8.2%) women had symptomatic vaginitis and 24 (10.8%) were carriers.
Candida albicans was the species most frequently isolated (44.2%), followed by Torulopsis glabrata (28%) and Saccharomyces cerevisiae (16.2%), from symptomatic and carrier patients.
The activity of acid proteinase was determined for C. albicans isolated from both symptomatic and carrier patients.
All 13 carriers showed low activity for aspartyl proteinase (score 1+), while 5 of 6 symptomatic patients showed higher activity (score 2+), with a significant difference (p=0.026).
In general, isolates of T glabrata and S. cerevisiae were less susceptible in vitro to fluconazole than isolates of C. albicans.
We did not find any differences in fluconazole MIC results among the C. albicans strains isolated from symptomatic and carrier patients.
On the other hand, the fluconazole MICs of T. glabrata and S. cerevisiae isolates showed statistically significant differences between symptomatic and carrier patients (p=0.009 and p=0.000, respectively).
The differences in proteinase secretion between the isolates from symptomatic and carrier patients suggest a correlation between proteinase production and vaginal candidiasis caused by C. albicans. (...)
Mots-clés Pascal : Vulvovaginite, Candidose, Mycose, Infection, Peptidases, Hydrolases, Enzyme, Antifongique, Candida, Fungi Imperfecti, Fungi, Thallophyta, Torulopsis, Saccharomyces, Ascomycetes, Epidémiologie, Prévalence, Activité biologique, Femme, Homme, In vitro, Italie, Europe, Appareil génital femelle pathologie, Vagin pathologie, Vulve pathologie, Vaginite, Vulvite
Mots-clés Pascal anglais : Vulvovaginitis, Candidiasis, Mycosis, Infection, Peptidases, Hydrolases, Enzyme, Antifungal agent, Candida, Fungi Imperfecti, Fungi, Thallophyta, Torulopsis, Saccharomyces, Ascomycetes, Epidemiology, Prevalence, Biological activity, Woman, Human, In vitro, Italy, Europe, Female genital diseases, Vaginal diseases, Vulvar diseases, Vaginitis, Vulvitis
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0432269
Code Inist : 002B05D02E. Création : 19/12/1997.