During recent decades much interest has been focused on the possibility of predicting and preventing atopic diseases during pregnancy.
The idea of being able to detect a predisposition early and take suitable environmental measures in order to avoid overt allergy is an attractive position.
Elevated cord IgE of around 1.0 IU/ml has been proposed as a predictor in western children.
However, there remains no information about the effect of maternal lifestyle during pregnancy on these levels.
Total IgE levels were therefore determined using Pharmacia CAP system and PRIST, with sensitivities of 0.01 kU/l and 0.25 kU/l, respectively, from serum samples taken from 1138 Japanese pairs of cord blood and pregnant women responding to a questionnaire regarding 17 health practices, intake of 32 food allergens and 5 environmental factors.
Of these, 28 (2.5%) pairs of samples were excluded from further analysis because of high contamination of IgA (>15.4 mg/ml) in cord blood.
Median cord blood IgE was 0.286 kU/l and geometric mean IgE was 66.25 kU/l in maternal sera using CAP system ; there was no significant correlation between maternal log (IgE) and cord blood IgE.
Similar results were obtained from PRIST, whose correlation with CAP system was significant (r=0.884, p<0.001 for maternal and r=0.765, p<0.001 for cord blood).
Multiple logistic analysis demonstrated that avoidance of simultaneous exposure to hens'eggs and cow's milk (relative risk=1.3, p<0. (...)
Mots-clés Pascal : Allergie, Atopie, IgE, Sang, Cordon ombilical, Mode de vie, Mère, Gestation, Alimentation, Facteur milieu, Marqueur biologique, Epidémiologie, Analyse quantitative, Taux, Facteur risque, Nouveau né, Homme, Japon, Asie, Santé et environnement, Immunopathologie
Mots-clés Pascal anglais : Allergy, Atopy, IgE, Blood, Umbilical cord, Life habit, Mother, Pregnancy, Feeding, Environmental factor, Biological marker, Epidemiology, Quantitative analysis, Rate, Risk factor, Newborn, Human, Japan, Asia, Health and environment, Immunopathology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0432262
Code Inist : 002B30A02A. Création : 19/12/1997.