This study attempts to explain the unexpected finding of an inverse population (ecological) relationship between mean systolic blood pressure levels and stroke death rates in 25 years follow-up of the Seven Countries Study, a cross-cultural study of cardiovascolar disease.
Sixteen cohorts of all men aged 40-59 in seven countries (one cohort in the USA, two in Finland, one in the Netherlands, three in Italy, two in Croatia (former Yugoslavia), three in Serbia (former Yugoslavia), two in Greece, two in Japan) were surveyed from 1958 to 1964.
Risk factors and personal characteristics were measured and follow-up for vital status and cause of death was then carried out over 25 years.
Analyses were based on comparisons of mean levels of risk factors and death rates within and among the 16 cohorts.
Mean entry population levels of systolic blood pressure among the cohorts were strongly and inversely related with their 25-year stroke death rates (R - 0.55 ; Cl - 0.81 and - 0.06 ; p=0.0276).
Within cohorts in contrast, the individual relation of blood pressure and stroke was strongly positive and significant in 14 of the 16 cohorts.
Mean population levels of serum cholesterol were inversely and strongly related to stroke death rates (R - 0.79 ; CI - 0.92 and - 0.46 ; p=0.0003), while the partial correlation coefficient of systolic blood pressure, computed in models including serum cholesterol, became small and not significant (-0.05 ; CI - 0.55 and+0.48 ; p=0.8537). (...)
Mots-clés Pascal : Accident cérébrovasculaire, Mortalité, Taux, Pression sanguine, Pression systolique, Etude comparative, Facteur risque, Homme, International, Etude multicentrique, Etude cohorte, Epidémiologie, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Cérébrovasculaire pathologie, Appareil circulatoire pathologie, Vaisseau sanguin pathologie
Mots-clés Pascal anglais : Stroke, Mortality, Rate, Blood pressure, Systolic pressure, Comparative study, Risk factor, Human, International, Multicenter study, Cohort study, Epidemiology, Nervous system diseases, Central nervous system disease, Cerebral disorder, Cerebrovascular disease, Cardiovascular disease, Vascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0432260
Code Inist : 002B17C. Création : 19/12/1997.