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  1. Molecular analysis of an outbreak of influenza in the United Kingdom.

    Article - En anglais

    The first outbreak of influenza virus in Europe in 1995/1996 occurred in a school in the south of England.

    RT-PCR-restriction analysis was performed on the HAI portion of influenza haemagglutinin gene amplified directly from clinical samples.

    These were taken at the onset of the outbreak and indicated co-circulation of two distinct genetic variants of influenza virus which were antigenically identical.

    Investigations of this nature demonstrate the genetic diversity of circulating variants of influenza and have the potential to provide information on molecular evolution of strains within closed populations.

    Mots-clés Pascal : Influenzavirus, Orthomyxoviridae, Virus, Virose, Infection, Réaction chaîne polymérase, Polymorphisme longueur fragment restriction, Séquence nucléotide, Mutation, Gène, Antigène, Angleterre, Grande Bretagne, Royaume Uni, Europe, Technique, Homme, Epidémiologie, Génétique épidémiologique, Biologie moléculaire

    Mots-clés Pascal anglais : Influenzavirus, Orthomyxoviridae, Virus, Viral disease, Infection, Polymerase chain reaction, Restriction fragment length polymorphism, Nucleotide sequence, Mutation, Gene, Antigen, England, Great Britain, United Kingdom, Europe, Technique, Human, Epidemiology, Epidemiologic genetics, Molecular biology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0432258

    Code Inist : 002B05C02C. Création : 19/12/1997.