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  1. Measuring health status in patients with skeletal metastases treated by surgery.

    Article - En anglais

    Since the introduction of the Functional Living Index-Cancer (FLIC)>10 years ago, a variety of general as well as disease-specific quality oflife (QOL) instruments have been developed and used as a means of assessing the success of clinical interventions.

    Clinicians faced with selecting an appropriate QOL measurement tool will need guidance in both the selection of the instrument and its evaluation for applicability to the patient group under study.

    In our examination ofthis issue, we analyzed the results ofadministering the FLIC and the more general SF-36 questionnaire to a group of 17 patients who had undergone orthopaedic surgery to correct problems associated with bone metastatic cancer.

    Because the SF-36 has been widely adopted as a general Health Status evaluation tool and because of its extensive validation it may be considered a gold standard providing a means of assessing the validity of disease-specific instruments such as the FLIC.

    Using multivariate regression, we built a model in which five of the eight health status dimensions of the SF-36 account for 77% of the variation in the FLIC scores for this group of patients (R2=0.77).

    The implication of this result is that most of the information (i.e., 77%) provided by the FLIC could be equivalently obtained using the more general, more widely validated SF-36.

    Despite the small sample size, half of the regression coefficients in this model achieved a high level of statistical significance (p<0.001). (...)

    Mots-clés Pascal : Etat sanitaire, Qualité vie, Prédiction, Tumeur maligne, Os, Homme, Stade avancé, Métastase, Chirurgie, Traitement, Démographie, Fiabilité, Analyse statistique, Système ostéoarticulaire pathologie

    Mots-clés Pascal anglais : Health status, Quality of life, Prediction, Malignant tumor, Bone, Human, Advanced stage, Metastasis, Surgery, Treatment, Demography, Reliability, Statistical analysis, Diseases of the osteoarticular system

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0431904

    Code Inist : 002B30A01A2. Création : 19/12/1997.