Platelet counts and aggregation measures in the incidence of ischaemic heart disease (IHD).
Although studies in those who have already experienced clinical episodes of ischaemic heart disease (IHD) have suggested properties of platelets influencing recurrence, there is limited information on the value of platelet tests in predicting first episodes of IHD.
One study has suggested that a raised platelet count and increased aggregability in response to adenosine diphosphate (ADP) may increase IHD incidence but the numbers of IHD events involved were small.
The larger Northwick Park Heart Study (NPHS) included platelet count and both ADP and adrenaline-induced aggregation and this paper presents their associations with subsequent IHD.
Platelet counts were performed in 1369 white NPHS men aged between 40 and 64 at recruitment, of whom 181 subsequently experienced a major episode of IHD over a follow-up period of 16.1 years.
Platelet count was unrelated to the incidence of IHD.
ADP-induced aggregation was performed in a random sample of 740 men in whom 66 IHD events occurred during the subsequent 10.1 years, aggregability being measured both as ED50, the ADP dose at which aggregation occurred at half its maximum velocity, and also as EMR, the maximum rate of aggregation achieved.
Neither measurement showed any association with IHD incidence, nor did similar measurements in 460 men in whom adrenaline-induced aggregation was also carried out. (...)
Mots-clés Pascal : Cardiopathie coronaire, Thrombocyte, Numération, Agrégation, Incidence, Epidémiologie, Angleterre, Grande Bretagne, Royaume Uni, Europe, Fonction thrombocytaire, Homme, Appareil circulatoire pathologie
Mots-clés Pascal anglais : Coronary heart disease, Platelet, Numeration, Aggregation, Incidence, Epidemiology, England, Great Britain, United Kingdom, Europe, Platelet function, Human, Cardiovascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0430819
Code Inist : 002B12A03. Création : 19/12/1997.