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  1. Mortality of workers exposed to methylene chloride employed at a plant producing cellulose triacetate film base.

    Article - En anglais


    To study mortality among 1785 employees of a factory that produced cellulose triacetate film base at Brantham in the United Kingdom.

    Also, to investigate patterns of mortality after exposure to methylene chloride ; in particular, mortality from liver and biliary tract cancer, lung cancer, pancreatic cancer, and cardiovascular disease.

    Subjects and methods-All male employees with a record of employment at the film factory in 1946-88.

    A total of 1473 subjects worked in jobs that entailed exposure to methylene chloride.

    The mean duration of exposure was nine years at 19 ppm (eight hour time weighted average).


    In the cohort, 334 deaths were identified up to 31 December 1994.

    Mortalities for the cohort were compared with national and local rates and expressed as standardised mortality ratios (SMR).

    In the subcohort of workers exposed to methylene chloride, substantially reduced mortalities compared with national and local rates were found for all causes, all cancers, and the principal cancer sites of interest.

    The significantly reduced lung cancer mortalities in exposed workers (SMR 48) seemed to reflect the restrictions on smoking at the workplace.

    In contrast, mortality from ischaemic heart disease in exposed workers, although lower than national rates (SMR 92), was slightly increased compared with local rates. (...)

    Mots-clés Pascal : Solvant organique, Industrie, Film photographique, Exposition professionnelle, Médecine travail, Toxicité, Homme, Mortalité, Epidémiologie, Royaume Uni, Europe, Etude cohorte, Méthane(dichloro)

    Mots-clés Pascal anglais : Organic solvent, Industry, Photographic film, Occupational exposure, Occupational medicine, Toxicity, Human, Mortality, Epidemiology, United Kingdom, Europe, Cohort study

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0430427

    Code Inist : 002B03L04. Création : 19/12/1997.

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