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  1. The nicotine inhaler in smoking cessation.

    Article - En anglais


    Nicotine replacement therapy has been shown to improve success rates in smoking cessation treatment.

    However, the available products cause adverse effects, which prevent some smokers from using them.

    A new method of delivering nicotine via inhaler supplies nicotine orally through inhalation from a plastic tube.

    This mode of delivering nicotine resembles smoking, as it includes handling and active inhalation.


    To assess the efficacy and safety of the nicotine inhaler as an aid in smoking cessation.


    A 1-year, randomized, double-blind, placebo-controlled study was conducted in a smoking cessation clinic.

    Two hundred forty-seven smokers who smoked at least 10 cigarettes per day and who had previously made a serious attempt to stop smoking using nicotine chewing gum were recruited through advertisements.

    Randomization to treatment or control conditions were made at the first group session, with 123 participants receiving nicotine inhalers and 124 receiving placebo inhalers.

    The inhalers were distributed at the second session and participants were allowed to use the inhalers for 6 months.

    Main Outcome Measure 

    Biochemically verified continuous abstinence from smoking after 2 and 6 weeks and at 3,6, and 12 months.


    Significantly more participants who had used the nicotine inhalers were continuously abstinent compared with those who had used the placebo inhalers.

    The respective success rates after 12 months were 28% and 18% (P=046). (...)

    Mots-clés Pascal : Tabagisme, Arrêt, Evaluation, Nicotine, Inhalateur, Randomisation, Analyse biochimique, Homme, Etude comparative, Toxicologie, Appareil respiratoire pathologie, Education santé, Vasodilatateur, Vitamine B

    Mots-clés Pascal anglais : Tobacco smoking, Shutdown, Evaluation, Nicotine, Inhaler, Randomization, Biochemical analysis, Human, Comparative study, Toxicology, Respiratory disease, Health education, Vasodilator agent, B-Vitamins

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0429067

    Code Inist : 002B03E. Création : 19/12/1997.