Background The increase in atopic diseases may be partly explicable by a decline of certain infectious diseases, or changes in childhood vaccination programmes, or both.
We investigated whether BCG vaccination against tuberculosis influences the development of atopy.
Methods We did a retrospective cohort study of 216 children with atopic heredity, born in Stockholm between 1989 and 1992, who received BCG vaccination when they were younger than 6 months, and 358 age-matched controls who had not been vaccinated.
Both groups attended Sachs'Children's Hospital, Stockholm, Sweden, during 1995-96 for assessment of atopic history and clinical signs of atopic disease.
All children also underwent skin-prick testing (SPT) and serum was analysed for allergen-specific IgE antibodies.
Serum from parents was also analysed for IgE antibodies.
Findings 77 (36%) children in the BCG group and 145 (41%) in the control group had a positive history or clinical signs of atopic disease.
In the vaccinated group, 26 (12%) children had one or more positive SPT, and 61 (31%) had circulating allergen-specific IgE antibodies, whereas in the control group, the numbers were 35 (10%) and 84 (27%) respectively.
Atopy was confirmed by serology in parents of almost two-thirds of the children in each group.
Other risk factors for atopic disease were evenly distributed between the two groups.
Mots-clés Pascal : BCG, Vaccination, Etude cohorte, Atopie, Facteur risque, Symptomatologie, Critère âge, Héréditaire, Enfant, Homme, Evaluation, Immunoprophylaxie, Organisation santé, Immunopathologie, Déterminisme génétique
Mots-clés Pascal anglais : BCG, Vaccination, Cohort study, Atopy, Risk factor, Symptomatology, Age criterion, Hereditary, Child, Human, Evaluation, Immunoprophylaxis, Public health organization, Immunopathology, Genetic inheritance
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0428947
Code Inist : 002B05A02. Création : 19/12/1997.