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  1. Helicobacter pylori infection and gastric cancer : A nested case-control study in a rural area of Japan.

    Article - En anglais

    We conducted a seroepidemiological nested case-control study to determine the association of gastric cancer with Helicobacter pylori infection and atrophic gastritis.

    A cohort of 2858 participants in an annual multiphasic health check-up were followed for eight years.

    Data for 45 gastric cancer cases and 225 sex-age-and address-matched control subjects were analyzed.

    Helicobacter pylori infection was determined by IgG antibodies, and atrophic gastritis was diagnosed by both serum pepsinogen I level (¾70 ng/ml) and the pepsinogen I/II ratio (¾3.0).

    Univariate analysis showed that Helicobacter pylori and atrophic gastritis were significantly associated with gastric cancer.

    In a multivariate analysis, atrophic gastritis was associated with significantly increased risk of cancer (odds ratio, 3.38 ; 95% confidence interval, 1.54-7.42) ; however, Helicobacter pylori was not associated with cancer (odds ratio, 1.84 ; 95% confidence interval, 0.59-5.72).

    These results suggest that Helicobacter pylori infection alone is not directly associated with gastric carcinogenesis but has an indirect relation to gastric cancer through the development of atrophic gastritis.

    Mots-clés Pascal : Gastrite atrophique, Campylobactériose, Bactériose, Infection, Helicobacter pylori, Spirillaceae, Spirillales, Bactérie, Carcinome, Estomac, Complication, Incidence, Association morbide, Pathogénie, Etude cas témoin, Homme, Appareil digestif pathologie, Estomac pathologie, Tumeur maligne

    Mots-clés Pascal anglais : Atrophic gastritis, Campylobacter infection, Bacteriosis, Infection, Helicobacter pylori, Spirillaceae, Spirillales, Bacteria, Carcinoma, Stomach, Complication, Incidence, Concomitant disease, Pathogenesis, Case control study, Human, Digestive diseases, Gastric disease, Malignant tumor

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0428493

    Code Inist : 002B13B01. Création : 19/12/1997.