Viruses are considered possible aetiologic agents of autoimmune disease.
Evidence suggests that human cytomegalovirus (HCMV) may be a pathogenetic factor in systemic lupus erythematosus (SLE).
We undertook a seroepidemiological study to determine whether HCMV infection is increased in patients with SLE.
Sero-epidemiologic data, indicative of virus prevalence, were obtained by enzyme immunoassay Results.
Eighty-eight of 97 serum samples (90. 7%) taken from adult patients with SLE were seropositi>, e for HCMV By contrast, HCMV was detected in only 32 of 50 (64.0%) adult patients with rheumatoid arthritis (RA) and 42 of 97 (43.3%) normal controls.
The odds ratio for HCMV prevalence in SLE/normal controls was 14.53 (95% Cl is 6.39 to 33. 04).
For comparison, data for herpes simplex virus-I (HSV-I) seropositivity were obtained from the same three groups.
Seventy-eight patients with SLE (80.4%), 40 patients with RA (80.0%) and 57 normal controls (58. 8%) were seropositive for this closely-related herpesvirus.
The data shows a specific and highly significant association between infection with HCMV and a clinical diagnosis of SLE.
Mots-clés Pascal : Lupus érythémateux, Disséminé, Pathogénie, Infection, Cytomegalovirus humain, Betaherpesvirinae, Herpesviridae, Virus, Prévalence, Epidémiologie, Sérum, Méthode immunoenzymatique, Homme, Peau pathologie, Tissu conjonctif pathologie, Maladie système, Maladie autoimmune, Immunopathologie, Virose
Mots-clés Pascal anglais : Lupus erythematosus, Disseminated, Pathogenesis, Infection, Human cytomegalovirus, Betaherpesvirinae, Herpesviridae, Virus, Prevalence, Epidemiology, Serum, Enzyme immunoassay, Human, Skin disease, Connective tissue disease, Systemic disease, Autoimmune disease, Immunopathology, Viral disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0428452
Code Inist : 002B07. Création : 19/12/1997.