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  1. Nephrotic syndrome in South African children : changing perspectives over 20 years.

    Article - En anglais

    We review our 20-year experience of 636 children with nephrotic syndrome (NS) in Durban, South Africa ; 306 (48.2%) were blacks, 307 (48.2%) Indians and 23 (3.6%) were a mixed group (coloured) ; 91 (14.3%) could not be categorised and were excluded from the analysis.

    In Indian children, 134 of 286 (46.8%) had biopsy-proven minimal change NS (MCNS) and 94.8% of these were steroid sensitive (SS) ; 60 (21%) had SSNS but without renal biopsy ; 59 (20.6%) had focal segmental glomerulosclerosis (FSGS), with only 4.4% of these being SS.

    In blacks, membranous nephropathy accounted for 40% of cases ; 86.2% were associated with hepatitis B virus antigens.

    Typical SSNS continues to be uncommon among blacks.

    Only 14.4% had either biopsy-proven SS-MCNS or SSNS ; 32 had MCNS lesions on biopsy, but 18 were steroid resistant (SR) ; 67 of 236 (28.4%) had FSGS, all of whom were SR.

    Among coloured patients, 5 of 23 (21.7%) had biopsy-proven SS-MCNS and or unbiopsied SSNS ; 10 (43.5%) had FSGS and 6 of 23 (26.1%) had membranous nephropathy.

    Proliferative lesions were present in only 2 of 23 (8.6%) coloured patients and was uncommon in all population groups.

    Overall mortality was 3.1%. In brief, this is the largest reported series of NS among children in Africa and shows a typical pattern in Indians, an unusual pattern of histological types in blacks and an intermediate picture in coloureds.

    Mots-clés Pascal : Néphrotique syndrome, Incidence, Origine ethnique, Forme clinique, Sensibilité, Chimiothérapie, Corticostéroïde, Evolution, Complication, Etude statistique, Enfant, Homme, République Sud Africaine, Afrique, Appareil urinaire pathologie, Rein pathologie, Néphropathie glomérulaire

    Mots-clés Pascal anglais : Nephrotic syndrome, Incidence, Ethnic origin, Clinical form, Sensitivity, Chemotherapy, Corticosteroid, Evolution, Complication, Statistical study, Child, Human, South Africa, Africa, Urinary system disease, Kidney disease, Glomerulonephritis

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0428369

    Code Inist : 002B14A01. Création : 19/12/1997.