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  1. Survival probabilities of Pugh-Child-PBC classified patients in the Euricterus primary biliary cirrhosis population, based on the Mayo Clinic prognostic model.

    Article - En anglais


    Estimation of prognosis becomes increasingly important in primary biliary cirrhosis (PBC) with advancing disease and also with regard to patient management.

    The ubiquitous used Pugh scoring for severity of disease is simple while the Mayo model which has been validated for survival estimates is more sophisticated.

    We wanted to investigate whether Pugh and Mayo scores correlate (they have 3 of 5 variables in common) and if so whether a survival probability based on Mayo data could be affixed on Pugh classes and scores obtained in the same patients.

    Methodology ; All variables used for Mayo Clinic Prognostic Model (Mayo) scoring and Pugh-Child-PBC (Pugh) scoring were available in 143 PBC patients of the Pan European database Euricterus.

    Pugh scores P5-P15 and has classes A (P5-6), B (P7-9) and C (P10-15).

    We subdivided P5 in P5A (patients with albumin>40 g/l plus prothrombin time ¾12 secs) and P5B (the other patients in P5).

    We designed a category Pugh Early (PE) for patients with P5A characteristics and bilirubin<17 mmol/l. Mayo scores R0-R15 - with 1-7 years survival probabilities S - and has risk classes Low (L), Intermediate (Int), High (H) and Very High (VH).


    The estimated survival probabilities of the 143 patients ranged from 88% at 7 years to 0% at 1 year, median 14% at 5 years.

    The Pugh and Mayo scores correlated r=0.87 (p<0.0001) and except age with P, all Mayo and Pugh variables correlated with both R and P at p<0.0001. (...)

    Mots-clés Pascal : Cirrhose biliaire, Primitif, Classification par stade, Echelle évaluation, Test score, Valeur prédictive, Survie, Symptomatologie, Etude statistique, Homme, Appareil digestif pathologie, Foie pathologie, Voie biliaire pathologie, Immunopathologie, Maladie autoimmune

    Mots-clés Pascal anglais : Biliary cirrhosis, Primitive, Stage classification, Evaluation scale, Score test, Predictive value, Survival, Symptomatology, Statistical study, Human, Digestive diseases, Hepatic disease, Biliary tract disease, Immunopathology, Autoimmune disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0428241

    Code Inist : 002B30A01A2. Création : 19/12/1997.