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  1. The next stage : Molecular epidemiology. Commentary.

    Article - En anglais

    The traditional approach in epidemiology of relating exposure to an environmental agent such as a drug or infective agent has been to measure an overall risk (i.e., average and then « adjust risk for demographic variables and other confounders »). An attempt is sometimes made to define a « susceptible » subgroup.

    The analyses are usually based on good statistical methodology rather than an understanding of the interaction of body of host and agent.

    A twofold risk for 1000 exposed versus nonexposed people could be an average twofold risk for all 1000 exposed or a 20-fold risk for 100 exposed individuals (i.e., a drug-host interaction).

    Clearly, finding the 100 individuals with a 20-fold risk has much greater clinical importance than a twofold risk for 1000 people.

    The world of epidemiology may be changing-we may soon he able to define risk based on genetic susceptibility, at least sometimes.

    Mots-clés Pascal : Epidémiologie moléculaire, Déterminisme génétique, Homme, Carcinogène, Médicament, Immunologie, Alimentation, Génotype, Facteur risque, Prévention, Etude générale, Génétique, Epidémiologie

    Mots-clés Pascal anglais : Molecular epidemiology, Genetic inheritance, Human, Carcinogen, Drug, Immunology, Feeding, Genotype, Risk factor, Prevention, General study, Genetics, Epidemiology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0423163

    Code Inist : 002B30A01A1. Création : 19/12/1997.