The traditional approach in epidemiology of relating exposure to an environmental agent such as a drug or infective agent has been to measure an overall risk (i.e., average and then « adjust risk for demographic variables and other confounders »). An attempt is sometimes made to define a « susceptible » subgroup.
The analyses are usually based on good statistical methodology rather than an understanding of the interaction of body of host and agent.
A twofold risk for 1000 exposed versus nonexposed people could be an average twofold risk for all 1000 exposed or a 20-fold risk for 100 exposed individuals (i.e., a drug-host interaction).
Clearly, finding the 100 individuals with a 20-fold risk has much greater clinical importance than a twofold risk for 1000 people.
The world of epidemiology may be changing-we may soon he able to define risk based on genetic susceptibility, at least sometimes.
Mots-clés Pascal : Epidémiologie moléculaire, Déterminisme génétique, Homme, Carcinogène, Médicament, Immunologie, Alimentation, Génotype, Facteur risque, Prévention, Etude générale, Génétique, Epidémiologie
Mots-clés Pascal anglais : Molecular epidemiology, Genetic inheritance, Human, Carcinogen, Drug, Immunology, Feeding, Genotype, Risk factor, Prevention, General study, Genetics, Epidemiology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0423163
Code Inist : 002B30A01A1. Création : 19/12/1997.