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  1. Rates of hypoglycemia in users of sulfonylureas.

    Article - En anglais

    Objective

    To identify the demographic and clinical characteristics of sulfonylurea users.

    To assess the risk of hypoglycemia in patients treated with sulfonylureas in clinical practice, and to characterize the risk in relation to the different drugs used.

    Research design and methods

    A cohort of 33,243 sulfonylurea users chosen from 719 clinical practices in the United Kingdom were identified through the VAMP-Research database.

    Information on demographic characteristics, medical diagnoses and use of medical services was obtained through the computerized records.

    For a stratified sample of 500 patients, general practioners completed a structured questionnaire on the duration, treatment, and complications of diabetes mellitus, obesity, alcohol use, and smoking history.

    Patients with a diagnosis of hypoglycemia, as recorded in the database within a time-window of a sulfonylurea prescription, were identified.

    Incidence rates per person-year of sulfonylurea therapy were estimated.

    Results

    Othet than a longer duration of diabetes in users of chlorpropamide, no differences were observed among users of different sulfonylurea agents with respect to diabetic complications, adequacy of diabetic control, obesity, smoking, and excessive alcohol consumption.

    A diagnosis of hypoglycemia during sulfonylurea therapy was recorded in 605 people over 34,052 person-years of sulfonylurea therapy, which converted into an annual risk of 1.8%. (...)

    Mots-clés Pascal : Sulfonylurées, Hypoglycémiant, Glibenclamide, Hypoglycémie, Epidémiologie, Diabète, Chimiothérapie, Traitement, Toxicité, Pharmacovigilance, Utilisation, Facteur risque, Homme, Royaume Uni, Europe, Endocrinopathie

    Mots-clés Pascal anglais : Sulfonylureas, Hypoglycemic agent, Glibenclamide, Hypoglycemia, Epidemiology, Diabetes mellitus, Chemotherapy, Treatment, Toxicity, Pharmacovigilance, Use, Risk factor, Human, United Kingdom, Europe, Endocrinopathy

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0421964

    Code Inist : 002B02U10. Création : 19/12/1997.