To monitor pregnancies in women with pre-existent insulin dependent diabetes for pregnancy loss, congenital malformations, and fetal growth in a geographically defined area of north west England.
Population cohort study.
10 maternity units in Cheshire, Lancashire, and Merseyside which had no regional guidelines for the management of pregnancy in diabetic women.
462 pregnancies in 355 women with insulin dependent diabetes from the 10 centres over five years (1990-4 inclusive).
Numbers and rates of miscarriages, stillbirths, and neonatal and postneonatal deaths ; prevalence of congenital malformations ; birth weight in relation to gestational age.
Among 462 pregnancies, 351 (76%) resulted in a liveborn infant 78 (17%) aborted spontaneously, nine (2%) resulted in stillbirth, and 24 (5%) were terminated.
Of the terminations, nine were for congenital malformation.
The stillbirth rate was 25.0/1000 total births (95% confidence interval 8.9 to 41.1) compared with a population rate of 5.0/1000, and infant mortality was 19.9/1000 live births (5.3 to 34.6) compared with 6.8/1000.
The prevalence of congenital malformations was 94.0/1000 live births (63.5 to 124.5) compared with 9.7/1000 in the general population.
When corrected for gestational age, mean birth weight in the sample was 1.3 standard deviations greater than that of infants of non-diabetic mothers. (...)
Mots-clés Pascal : Gestation, Etude cohorte, Association, Diabète insulinodépendant, Prévalence, Facteur risque, Malformation, Congénital, Prévention, Femelle, Homme, Appareil génital femelle pathologie, Mère pathologie, Endocrinopathie, Immunopathologie, Maladie autoimmune
Mots-clés Pascal anglais : Pregnancy, Cohort study, Association, Insulin dependent diabetes, Prevalence, Risk factor, Malformation, Congenital, Prevention, Female, Human, Female genital diseases, Maternal diseases, Endocrinopathy, Immunopathology, Autoimmune disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0417313
Code Inist : 002B20F02. Création : 19/12/1997.