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  1. Genetic influences in end-stage osteoarthritis : Sibling risks of hip and knee replacement for idiopathic osteoarthritis.

    Article - En anglais

    From a prospective, cross-sectional survey of 402 patients who had a total hip (THR) or a total knee (TKR) replacement for idiopathic osteoarthritis (OA) at a major centre, we determined the prevalence of these replacements for idiopathic OA in their 1171 siblings and 376 spouses.

    Using spouses as controls, the relative risk of THR in siblings was 1.86 (95% CI 0.93 to 3.69).

    The relative risk for TKR in siblings v spouses was 4.8 (95% CI 0.64 to 36.4) whereas the risk for the combined outcome measure of THR or TKR was 2.32 (95% CI 1.22 to 4.43) when siblings and spouses over 64 years of age were compared.

    Using a threshold liability model (Falconer), the heritability of end-stage OA of the hip was estimated at 27%. The increased risks of joint replacement for severe, idiopathic OA which we found in siblings suggest that genetic influences are important in end-stage OA of the hip and knee.

    Mots-clés Pascal : Arthrose, Evolutivité, Stade avancé, Héritabilité, Facteur risque, Etude longitudinale, Epidémiologie, Prévalence, Homme, Prothèse, Genou, Hanche, Traitement, Système ostéoarticulaire pathologie, Arthropathie, Maladie dégénérative, Chirurgie orthopédique

    Mots-clés Pascal anglais : Osteoarthritis, Evolutivity, Advanced stage, Heritability, Risk factor, Follow up study, Epidemiology, Prevalence, Human, Prosthesis, Knee, Hip, Treatment, Diseases of the osteoarticular system, Arthropathy, Degenerative disease, Orthopedic surgery

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0416956

    Code Inist : 002B15E. Création : 19/12/1997.