A study of autoantibodies and circulating immune complexes in mercury-exposed chloralkali workers.
Inorganic mercury may cause immunologically mediated disease : e.g., glomerulonephritis, acrodynia, and contact allergy.
Animal models have demonstrated the importance of genetic factors in determining susceptibility and resistance to autoimmunity, as well as the specific manifestation of the autoimmune response.
Findings in groups of workers with occupational exposure to inorganic mercury have been inconsistent.
To investigate whether an immune response, caused by exposure to inorganic mercury (Hg), could be shown in occupationally exposed workers.
Immunoglobulin G (IgG), antinuclear autoantibodies, antibodies against thyroid, stomach or kidney antigens using indirect immunofluorescence, antibodies against glomerular basement membrane using ELISA, and circulating immune complexes in serum, and albumin in urine, were examined in Hg-exposed workers and controls.
The two groups, 41 male chloralkali workers exposed to Hg vapour (mean exposure time 9 years) and 41 unexposed controls were age-matched and recruited from the same company.
Hg concentrations in whole blood (B-Hg), plasma (P-Hg), and urine (U-Hg) were determined using cold vapor atomic spectrometry.
The mean B-Hg, P-Hg and U-Hg levels were 46 nmol/l, 37 nmol/l, and 27 mug/g creatinine in the exposed group, and 17 nmol/l, 6.9 nmol/l, and 3.4 mug/g creatinine in the referents. (...)
Mots-clés Pascal : Mercure, Métal lourd, Toxicité, Exposition professionnelle, Médecine travail, Réponse immune, Immunopathologie, Autoimmunité, Autoanticorps, Immuncomplexe, Homme
Mots-clés Pascal anglais : Mercury, Heavy metal, Toxicity, Occupational exposure, Occupational medicine, Immune response, Immunopathology, Autoimmunity, Autoantibody, Immune complex, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0414684
Code Inist : 002B03L05. Création : 19/12/1997.