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  1. Second malignant neoplasms in patients treated on SIOP Wilms tumour studies and trials 1,2,5, and 6.

    Article - En anglais

    The incidence of second malignant neoplasms (SMNs) was investigated among 1,988 patients with complete data, enrolled in the SIOP Wilms tumor trials and studies 1,2,5, and 6, treated between September 1971 and October 1987.

    By the end of 1992, eight SMNs were documented, whereas only 1.3 were expected (standardized incidence ratio [SIR]=4.15 ; 95% Cl=1.79,8.17).

    The risk increases in the first 10 years from diagnosis, while no apparent excess of risk is observed in the subsequent periods.

    This finding however is difficult to interpretdue to the low statistical power.

    The cu mulative incidence of a second cancer observed at 15 years after Wilms tumor diagnosis was 0.65%. Six SMNs were registered in the cohort of patients treated in the SIOP studies 1,2 and 5 (999 cases) compared to the two cases observed in the SIOP6 cohort (989 cases).

    If the suggested reduced incidence of second cancers between SIOP1-5 and SIOP6 patient cohorts is confirmed by longer follow-up, it might reflect changes in the treatment protocols.

    Mots-clés Pascal : Tumeur Wilms, Enfant, Homme, Adolescent, Chimiothérapie, Radiothérapie, Complication, Second cancer, Incidence, Epidémiologie, Etude cohorte, Etude longitudinale, Anticancéreux, Appareil urinaire pathologie, Rein pathologie, Tumeur maligne

    Mots-clés Pascal anglais : Wilms tumor, Child, Human, Adolescent, Chemotherapy, Radiotherapy, Complication, Second cancer, Incidence, Epidemiology, Cohort study, Follow up study, Antineoplastic agent, Urinary system disease, Kidney disease, Malignant tumor

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0413894

    Code Inist : 002B14D01. Création : 19/12/1997.