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  1. Klebsiella and extended spectrum B-lactamases.

    Article - En anglais

    Copyright (c) 1997 Elsevier Science Ireland Ltd.

    All rights reserved.

    During the past 14 years a rapid, world-wide increase in prevalence of Klebsiella pneumoniae resistant to late generation cephalosporins has occurred.

    A growing number of newly identified plasmid encoded B-lactam hydrolyzing enzymes has broadened the spectrum of primitive B-lactamases allowing inactivation of a wide variety of B-lactam agents.

    The extrachromosomal genes which code for these enzymes often exist with genes expressing resistance to several other classes of antibacterial agents, potentially arming Klebsiella pneumoniae with resistance to all therapeutically available antibiotics.

    More focused surveillance studies and individualized strategies within institutions are necessary to reduce this insidious trend. 1997 Elsevier Science B.V.

    Mots-clés Pascal : Céphalosporine dérivé, Antibiotique, Antibactérien, Résistance, Klebsiella pneumoniae, Enterobacteriaceae, Bactérie, Plasmide, Mutation, Spectre activité, Article synthèse, Sensibilité résistance, Pouvoir pathogène, Virulence, Surveillance, Recommandation, bêta-Lactamase, Hydrolases, Enzyme

    Mots-clés Pascal anglais : Cephalosporin derivatives, Antibiotic, Antibacterial agent, Resistance, Klebsiella pneumoniae, Enterobacteriaceae, Bacteria, Plasmid, Mutation, Activity spectrum, Review, Sensitivity resistance, Pathogenicity, Virulence, Surveillance, Recommendation, bêta-Lactamase, Hydrolases, Enzyme

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0413520

    Code Inist : 002A05B10. Création : 19/12/1997.