This study assessed the potential impact of fetal ultrasound screening on the number of newborns affected by cardiac anomalies.
A decision model was developed that included the prevalence and history of congenital heart disease, characteristics of ultrasound, risk of abortion, and attitude toward pregnancy termination.
Probabilities were obtained with a literature survey ; sensitivity analysis showed their influence on expected outcomes.
Presently, screening programs may prevent the birth of approximately 1300 severely affected newborns per million secondtrimester pregnancies.
However, over 2000 terminations of pregnancy would be required, 750 of which would have ended in intrauterine death or spontaneous abortion.
Further, 9900 false-positive screening results would occur, requiring referral.
Only the sensitivity of routine screening and attitude toward termination of pregnancy appeared to influence the yield substantially.
The impact of routine screening for congenital heart disease appeared relatively small.
Further data may be required to fully assess the utility of prenatal screening.
Mots-clés Pascal : Cardiopathie, Maladie congénitale, Dépistage, Prénatal, Exploration ultrason, Evaluation, Analyse décision, Homme, Politique sanitaire, Population, Efficacité, Appareil circulatoire pathologie
Mots-clés Pascal anglais : Heart disease, Congenital disease, Medical screening, Prenatal, Sonography, Evaluation, Decision analysis, Human, Health policy, Population, Efficiency, Cardiovascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0413225
Code Inist : 002B30A03A. Création : 19/12/1997.