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  1. Potential biomarkers of benzene exposure.

    Article - En anglais

    Biological markers or biomarkers of exposure are indicators for the evaluation of the internal dose of a xenobiotic.

    Biomarkers integrate exposure from all routes and sources.

    This review presents a short overview of potential biomarkers of benzene exposure currently under investigation, the methodology used for their determination, and experimental findings and their usefulness and specificity in assessing exposure to benzene.

    Potential biomarkers of benzene exposure are benzene, benzene metabolites, and adducts formed by reactive benzene metabolites with cellular constituents.

    The potential biomarkers of benzene exposure described in this review are :

    • (1) benzene, the parent hydrocarbon ;

    • (2) ring-hydroxylated urinary metabolites, phenol, catechol, hydroquinone, and 1,2,4-trihydroxybenzene ;

    • (3) trans, trans-muconic acid, a urinary ring-opened metabolite ;

    • (4) N-acetyl-S- (2,5-dihydroxyphenyl) - L-cysteine, a urinary metabolite of benzene, phenol, and hydroquinone ;

    • (5) S-phenylmercapturic acid, a glutathione-derived adduct ;

    • (6) N7-phenylguanine, a DNA adduct ;

    • and (7) S-phenylcysteine and N-phenyl-valine, hemoglobin/protein-derived adducts.

    Mots-clés Pascal : Article synthèse, Marqueur biologique, Carcinogène, Polluant, Hydrocarbure, Benzène, Métabolite, Phénols, Aminoacide soufré, Sulfure organique, Guanine dérivé, Diacide carboxylique, Composé diénique conjugué, Sélectivité, Dose faible, Stéréoisomère trans, Homme, Exposition professionnelle, Médecine travail, Homocystéine(N-acétyl-S-phényl), Hexa-2,4-diènedioïque acide, Cystéine(S-phényl), Guanine(7-phényl)

    Mots-clés Pascal anglais : Review, Biological marker, Carcinogen, Pollutant, Hydrocarbon, Benzene, Metabolite, Phenols, Sulfur containing aminoacid, Organic sulfide, Guanine derivatives, Dicarboxylic acid, Conjugated dienic compound, Selectivity, Low dose, Trans stereoisomer, Human, Occupational exposure, Occupational medicine

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0410869

    Code Inist : 002B04E02. Création : 19/12/1997.