Objectives-It was hypothesised from an epidemiological investigation that a formula change from Acramin FWR (a polyurea) to Acramin FWN (a polyamideamine) had led to severe pulmonary disease in textile printing sprayers in Spain and Algeria.
To verify this, the pulmonary toxicity of the components of the paint systems involved was assessed in experimental animals.
Methods-Individual components and relevant mixtures, diluted in phosphate buffered saline, were given by intratracheal instillation of 2 ml/kg to hamsters.
Pulmonary toxicity was assessed on days 3,7,14,28, and 92 after a single intratracheal instillation, by histology and by measuring wet and dry lung weight, protein concentration, the activities of lactate dehydrogenase, alkaline phosphatase, bêta-N-acetyl-glucosaminidase, and y-glutamyltransferase, inflammatory cell number and distribution in bronchoalveolar lavage fluid (BALF), and hydroxyproline content in dried lung tissue.
Based on the doses that killed 50% of the animals (LD50s), the various components were found to be 10 to 1250 times more toxic when given intratracheally than when given orally (according to reported oral LD50s in rats).
Acramin FWN, Acramin FWR, Acrafix FHN, or their mixtures caused lung damage.
Protein concentration, enzyme activities, total cell number, and percentage of polymorphonuclear neutrophils were increased in BALF during the first week after intratracheal instillation. (...)
Mots-clés Pascal : Industrie textile, Colorant, Toxicité, Espagne, Europe, Algérie, Afrique, Exposition professionnelle, Médecine travail, Homme, Hamster, Rodentia, Mammalia, Vertebrata, Animal, Voie intratrachéale, Appareil respiratoire pathologie, Poumon, Acramine
Mots-clés Pascal anglais : Textile industry, Dyes, Toxicity, Spain, Europe, Algeria, Africa, Occupational exposure, Occupational medicine, Human, Hamster, Rodentia, Mammalia, Vertebrata, Animal, Intratracheal administration, Respiratory disease, Lung
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0410491
Code Inist : 002B03L06. Création : 19/12/1997.