ObjectieTo measure in vivo the cadmium concentrations in kidney cortex (kidney-Cd) and in superficial liver tissue (liver-Cd) of nickel cadmium battery workers, and to compare the results with other commonly used estimates of cadmium exposure (current concentrations of cadmium in blood (B-Cd) and urine (U-Cd)) or repeated measurements of cadmium in workplace air (CumAir-Cd).
MethodThe study comprised 30 workers with a range of duration of exposure of 11-51 years. 13 subjects were currently employed, whereas the other 17 had a median period without occupational exposure of eight years before the measurements.
The in vivo measurements were made with an x ray fluorescence technique permitting average detection limits of 30 and 3 mug cadmium per g tissue in kidney and liver, respectively.
19 of 30 (63%) people had kidney-Cd and 13 of 27 (48%) had liver-Cd above the detection limits.
Kidney-Cd ranged from non-detectable to 350 mug/g and liver-Cd from non-detectable to 80 mug/lg.
The median kidney-Cd and liver-Cd were 55 muglg and 3 muglg, respectively.
Kidney-Cd correlated significantly with B-Cd (rs 0.49) and U-Cd (rs 0.70), whereas liver-Cd correlated significantly with U-Cd (r, 0.58).
Neither kidney-Cd nor liver-Cd correlated with the CumAir-Cd.
The prevalence of bêta2-microglobulinurea increased with increased liver-Cd.
Conclusions-Current U-Cd can be used to predict the kidney-Cd and liver-Cd measured in vivo. (...)
Mots-clés Pascal : Batterie, Industrie automobile, Cadmium, Métal lourd, Nickel, Rein, Foie, Toxicité, Exposition professionnelle, Médecine travail, Taux, Liquide biologique, Sang, Urine, Homme, Teneur air ambiant, Lieu travail
Mots-clés Pascal anglais : Battery, Automobile industry, Cadmium, Heavy metal, Nickel, Kidney, Liver, Toxicity, Occupational exposure, Occupational medicine, Rate, Biological fluid, Blood, Urine, Human, Ambient air concentration, Work place
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0410490
Code Inist : 002B03L05. Création : 19/12/1997.