ObjectieTo investigate the contribution of exposure to asbestos through different routes in the development of mesothelioma.
185 confirmed cases of mesothelioma and 160 controls were identified, when death had occurred between 1979 and 1991 in four health districts in Yorkshire.
The surviving relatives were interviewed to ascertain lifetime exposure to asbestos.
Adjusted odds ratios (ORs) of exposure to asbestos (through occupational, paraoccupational, and residential routes) were calculated for cases and were compared with controls.
Likely or possible occupational exposure to asbestos was more common in cases than in controls (OR 5.6,95% confidence interval (95% CI) 3.1 to 10.1).
After excluding those with likely or possible occupational exposure, likely or possible paraoccupational exposure was more common in cases than controls (OR 5.8,95% CI 1.8 to 19.2).
Only six cases of mesothelioma were identified as being solely exposed to asbestos through their residence, compared with nine controls.
The OR for residential exposure to asbestos varied between 1.5 and 6.6, depending on which potential industrial sources were included, but the 95% CIs were so wide that slightly reduced or greatly increased odds comparing cases with controls could not be excluded.
Conclusion-Study results support previous evidence that occupational and paraoccupational exposure to asbestos is associated with developing mesothelioma. (...)
Mots-clés Pascal : Amiante, Fibre minérale, Toxicité, Mésothéliome malin, Appareil respiratoire pathologie, Exposition professionnelle, Non professionnel, Epidémiologie, Angleterre, Grande Bretagne, Royaume Uni, Europe, Milieu familial, Zone résidentielle, Proximité, Industrie, Homme, Tumeur maligne
Mots-clés Pascal anglais : Asbestos, Mineral fiber, Toxicity, Malignant mesothelioma, Respiratory disease, Occupational exposure, Non occupational, Epidemiology, England, Great Britain, United Kingdom, Europe, Family environment, Residential zone, Proximity, Industry, Human, Malignant tumor
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0410416
Code Inist : 002B03L03. Création : 19/12/1997.